The extracellular matrix and perineuronal nets in memory

JW Fawcett, M Fyhn, P Jendelova, JCF Kwok… - Molecular …, 2022 - nature.com
All components of the CNS are surrounded by a diffuse extracellular matrix (ECM)
containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans …

The role of the hippocampus in the consolidation of emotional memories during sleep

É Pronier, JF Morici, G Girardeau - Trends in Neurosciences, 2023 - cell.com
Episodic memory relies on the hippocampus, a heterogeneous brain region with distinct
functions. Spatial representations in the dorsal hippocampus (dHPC) are crucial for …

Hippocampal CA2 sharp-wave ripples reactivate and promote social memory

A Oliva, A Fernández-Ruiz, F Leroy, SA Siegelbaum - Nature, 2020 - nature.com
The consolidation of spatial memory depends on the reactivation ('replay') of hippocampal
place cells that were active during recent behaviour. Such reactivation is observed during …

Tuned geometries of hippocampal representations meet the computational demands of social memory

LM Boyle, L Posani, S Irfan, SA Siegelbaum, S Fusi - Neuron, 2024 - cell.com
Social memory consists of two processes: the detection of familiar compared with novel
conspecifics and the detailed recollection of past social episodes. We investigated the …

A hypothalamic novelty signal modulates hippocampal memory

S Chen, L He, AJY Huang, R Boehringer, V Robert… - Nature, 2020 - nature.com
The ability to recognize information that is incongruous with previous experience is critical
for survival. Novelty signals have therefore evolved in the mammalian brain to enhance …

A circuit from hippocampal CA2 to lateral septum disinhibits social aggression

F Leroy, J Park, A Asok, DH Brann, T Meira, LM Boyle… - Nature, 2018 - nature.com
Although the hippocampus is known to be important for declarative memory, it is less clear
how hippocampal output regulates motivated behaviours, such as social aggression. Here …

5-HT modulation of a medial septal circuit tunes social memory stability

X Wu, W Morishita, KT Beier, BD Heifets, RC Malenka - Nature, 2021 - nature.com
Social memory—the ability to recognize and remember familiar conspecifics—is critical for
the survival of an animal in its social group,. The dorsal CA2 (dCA2),–and ventral CA1 …

[HTML][HTML] An integrated index: engrams, place cells, and hippocampal memory

TD Goode, KZ Tanaka, A Sahay, TJ McHugh - Neuron, 2020 - cell.com
The hippocampus and its extended network contribute to encoding and recall of episodic
experiences. Drawing from recent anatomical, physiological, and behavioral studies, we …

[HTML][HTML] The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation

CR Lee, A Chen, KM Tye - Cell, 2021 - cell.com
Social homeostasis is the ability of individuals to detect the quantity and quality of social
contact, compare it to an established set-point in a command center, and adjust the effort …

Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

ML Phillips, HA Robinson, L Pozzo-Miller - elife, 2019 - elifesciences.org
Inputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are
implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC …