Both heparanase and syndecan-1 are known to be present and active in disease
pathobiology. An important feature of syndecan-1 related to its role in pathologies is that it …

Beyond anticoagulation, the therapeutic potential of heparin derivatives and heparan sulfate
(HS) mimetics (functionally defined HS mimetics) in oncology is related to their ability to bind …

Increased extracellular matrix (ECM) formation and matrix metalloprotease (MMP)‐mediated
ECM degradation are parts of tumorgenesis and generates collagen fragments that are …

Micro RNA s are small noncoding RNA s acting as physiological regulators of gene
expression at the post‐transcriptional level. In cancer, the expression of micro RNA s is …

In an era when cancer glycobiology research is exponentially growing, we are witnessing a
progressive translation of the major scientific findings to the clinical practice with the …

Heparan sulfate proteoglycans (HSPGs) play important roles in cancer initiation and
progression, by interacting with the signaling pathways that affect proliferation, adhesion …

Targeting heparan sulfate proteoglycans (HSPGs) and enzymes involved in heparan sulfate
(HS) chain editing is emerging as a new anticancer strategy. The involvement of HSPGs in …

Background Plant lectins have attracted great interest in cancer studies due to their
antitumor activities. These proteins or glycoproteins specifically and reversibly bind to …

Gold nanoparticles are elective candidate for cancer therapy. Current efforts are devoted to
developing innovative methods for their synthesis. Besides, understanding their interaction …

Glycosaminoglycans are integral part of the dynamic extracellular matrix (ECM) network that
control crucial biochemical and biomechanical signals required for tissue morphogenesis …