Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell
microenvironment provides factors and elements that play significant roles in controlling the …

Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …

In adults, human hematopoietic stem and progenitor cells (HSPCs) reside in the bone
marrow (BM) microenvironment. Our understanding of human hematopoiesis and the …

Abstract Two-dimensional (2D) cell cultures, in which cells grow in flat layers on plastic
surfaces, are considered the standard model for use in drug screening and for biological …

The human bone marrow (hBM) is a complex organ critical for hematopoietic and immune
homeostasis, and where many cancers metastasize. Understanding the fundamental …

Human malignant hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow
(BM) niches, which remain challenging to explore due to limited in vivo accessibility and …

The extracellular matrix interacts with cancer cells and is a key factor in the development of
cancer. Traditional two-dimensional models cannot mimic the natural in situ environment of …

Faithful modeling of tissues and organs requires the development of systems reflecting their
dynamic 3D cellular architecture and organization. Current technologies suffer from a lack of …

We engineered an in vitro model of bioartificial 3D bone organoid consistent with an
anatomical and vascular microenvironment common to mammalian flat and short bones. To …

In hematological malignancies, leukemias or myelomas, malignant cells present bone
marrow (BM) homing, in which the niche contributes to tumor development and drug …