The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms

H Yaribeygi, M Maleki, T Sathyapalan, A Sahebkar - Life sciences, 2019 - Elsevier
C-peptide is a small peptide connecting two chains of proinsulin molecule and is dissociated
before the release of insulin. It is secreted in an equimolar amount to insulin from the …

Physiological effects of nutrients on insulin release by pancreatic beta cells

M Losada-Barragán - Molecular and Cellular Biochemistry, 2021 - Springer
Obesity and type 2 diabetes (T2D) are growing health problems associated with a loss of
insulin sensitivity. Both conditions arise from a long-term energy imbalance, and frequently …

Hypoglycemic effects of Auricularia auricula polysaccharides on high fat diet and streptozotocin-induced diabetic mice using metabolomics analysis

N Liu, X Chen, J Song, M Chen, P Gong, W Jia, G Li - Food & Function, 2021 - pubs.rsc.org
This study evaluated the hypoglycemic effect of Auricularia auricula polysaccharides (AAPs)
on streptozotocin-induced type 2 diabetes mellitus (T2DM) mice using metabolomic …

[HTML][HTML] Dietary N-carbamylglutamate and L-arginine supplementation improves redox status and suppresses apoptosis in the colon of intrauterine growth-retarded …

H Zhang, Y Zheng, X Zha, X Liu, Y Ma, JJ Loor… - Animal Nutrition, 2022 - Elsevier
Previous studies have revealed that dietary N-carbamylglutamate (NCG) or L-arginine (Arg)
improves small intestinal integrity and immune function in suckling Hu lambs that have …

Early time course of oxidative stress in hippocampal synaptosomes and cognitive loss following impaired insulin signaling in rats: Development of sporadic …

MA Ansari, MS Rao, A Al-Jarallah, FM Babiker - Brain Research, 2023 - Elsevier
Oxidative stress, caused by impaired insulin signaling, plays a pivotal role in the
pathogenesis of sporadic Alzheimer's disease (sAD). We investigated the oxidative stress …

Potent anti-inflammatory and anti-apoptotic activities of electrostatically complexed C-peptide nanospheres ameliorate diabetic nephropathy

AK Singh, SA Salunkhe, D Chitkara, A Mittal - Biomaterials Advances, 2024 - Elsevier
In the present era of “Diabetic Pandemic”, peptide-based therapies have generated
immense interest however, are facing odds due to inevitable limitations like stability, delivery …

Rivastigmine ameliorates indomethacin experimentally induced gastric mucosal injury via activating α7nAChR with inhibiting oxidative stress and apoptosis

HM Khalaf, SM Ahmed, NN Welson… - … of Biochemical and …, 2022 - Wiley Online Library
The current study aimed to investigate the potential ameliorative role of Rivastigmine (RIVA),
the anti‐Alzheimer drug, against the gastric mucosal injury caused by indomethacin (IND) …

Tilianin protects diabetic retina through the modulation of Nrf2/TXNIP/NLRP3 inflammasome pathways

Y Zhang, Z Gao, X Gao, Z Yuan, T Ma… - Journal of …, 2020 - dl.begellhouse.com
Oxidative stress and inflammation are regarded as prime reasons for the progression and
development of diabetic retinopathy. Currently, nuclear factor erythroid-2-related factor 2 …

Effects of rhaponticin on retinal oxidative stress and inflammation in diabetes through NRF2/HO‐1/NF‐κB signalling

Q Shi, Y Cheng, X Dong, M Zhang… - … of Biochemical and …, 2020 - Wiley Online Library
Oxidative stress and inflammation have long been considered to be responsible for the
development and progression of diabetic retinopathy. On the other hand, rhaponticin (RN) …

[PDF][PDF] Evaluation the effects of insulin on oxidant/antioxidant status in type 1 diabetic patients

AAY Almulathanon, JA Mohammad, TA Allwash - Pharmacia, 2021 - pharmacia.pensoft.net
Earlier works have revealed increased generation of reactive oxygen species (ROS) and
decreased antioxidant levels in type 1 diabetes mellitus (T1DM). The current study aimed to …