Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles

MJ Ernsting, M Murakami, A Roy, SD Li - Journal of controlled release, 2013 - Elsevier
Nanoparticle drug delivery to the tumor is impacted by multiple factors: nanoparticles must
evade clearance by renal filtration and the reticuloendothelial system, extravasate through …

A review of indocyanine green fluorescent imaging in surgery

JT Alander, I Kaartinen, A Laakso… - … journal of biomedical …, 2012 - Wiley Online Library
The purpose of this paper is to give an overview of the recent surgical intraoperational
applications of indocyanine green fluorescence imaging methods, the basics of the …

[HTML][HTML] Step-index optical fiber made of biocompatible hydrogels

M Choi, M Humar, MS Kim, SH Yun - Advanced materials (Deerfield …, 2015 - ncbi.nlm.nih.gov
The limited penetration of light into biological tissue poses a formidable challenge in many
applications of light in biomedicine. Although a few approaches, such as near-infrared …

Quantification of fluorescence angiography: Toward a reliable intraoperative assessment of tissue perfusion-A narrative review

CD Lütken, MP Achiam, J Osterkamp… - … archives of surgery, 2021 - Springer
Background Accurate intraoperative assessments of tissue perfusion are essential in all
forms of surgery. As traditional methods of perfusion assessments are not available during …

Optimizing quantitative fluorescence angiography for visceral perfusion assessment

CD Lütken, MP Achiam, MB Svendsen, L Boni… - Surgical …, 2020 - Springer
Background Compromised tissue perfusion is a significant risk factor for anastomotic
leakage after intestinal resection, leading to prolonged hospitalization, risk of recurrence …

Analysis of factors affecting 5-ALA fluorescence intensity in visualizing glial tumor cells—Literature review

M Mazurek, D Szczepanek, A Orzyłowska… - International journal of …, 2022 - mdpi.com
Glial tumors are one of the most common lesions of the central nervous system. Despite the
implementation of appropriate treatment, the prognosis is not successful. As shown in the …

Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers

F Zhang, P Mastorakos, MK Mishra, A Mangraviti… - Biomaterials, 2015 - Elsevier
Effective blood–brain tumor barrier penetration and uniform solid tumor distribution can
significantly enhance therapeutic delivery to brain tumors. Hydroxyl-functionalized …

Characteristics of fluorescent intraoperative dyes helpful in gross total resection of high-grade gliomas—A systematic review

M Mazurek, B Kulesza, F Stoma, J Osuchowski… - Diagnostics, 2020 - mdpi.com
Background: A very important aspect in the treatment of high-grade glioma is gross total
resection to reduce the risk of tumor recurrence. One of the methods to facilitate this task is …

Intraprocedural artificial intelligence for colorectal cancer detection and characterisation in endoscopy and laparoscopy

NP Hardy, P Mac Aonghusa, PM Neary… - Surgical …, 2021 - journals.sagepub.com
In this article, we provide an evidence-based primer of current tools and evolving concepts
in the area of intraprocedural artificial intelligence (AI) methods in colonoscopy and …

Tumor heterogeneity and nanoparticle-mediated tumor targeting: the importance of delivery system personalization

KL Swetha, A Roy - Drug delivery and translational research, 2018 - Springer
After the discovery of the enhanced permeability and retention effect in 1986, it was
envisioned that nanoparticle-mediated tumor-targeted delivery of chemotherapeutics would …