Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substania nigra (SN) and is associated with progressive …

Cancers and neurological disorders are two major types of diseases. We previously
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …

Protein phosphorylation, catalyzed by kinases, is an important biochemical process, which
plays an essential role in multiple cell signaling pathways. Meanwhile, protein-protein …

ZNF746 was identified as parkin‐interacting substrate (PARIS). Investigating its
pathophysiological properties, we find that PARIS undergoes liquid–liquid phase separation …

Parkinson's disease is the second most common form of neurodegeneration, and it poses a
major threat to the quality of life of older adults. Stem cell transplantation, which has attracted …

Parkinson's disease is the second most prevalent neurodegenerative disease and
contributes significantly to morbidity globally. Currently, no disease-modifying therapies exist …

The aggregation of aminoacyl transfer RNA synthetase complex-interacting multifunctional
protein-2 (AIMP2) accelerates α-synuclein aggregation via direct interaction, leading to …

The E3 ubiquitin ligase parkin plays neuroprotective functions in the brain and the deficits of
parkin's ligase function in Parkinson's disease (PD) is associated with reduced survival of …

Parkinson's disease is the second most common neurodegenerative disorder. Although it is
clear that dopaminergic neurons degenerate, the underlying molecular mechanisms are still …

Parkinson's disease (PD) is a neurodegenerative disorder with motor symptoms like
bradykinesia, tremors, and balance issues. The pathology is recognized by progressively …