Establishing electron diffraction in chemical crystallography

T Gruene, JJ Holstein, GH Clever… - Nature Reviews Chemistry, 2021 - nature.com
The emerging field of 3D electron diffraction (3D ED) opens new opportunities for structure
determination from sub-micrometre-sized crystals. Although the foundations of this …

Electron diffraction of 3D molecular crystals

A Saha, SS Nia, JA Rodríguez - Chemical Reviews, 2022 - ACS Publications
Electron crystallography has a storied history which rivals that of its more established X-ray-
enabled counterpart. Recent advances in data collection and analysis have sparked a …

The Elusive Structure of Levocetirizine Dihydrochloride Determined by Electron Diffraction

DP Karothu, Z Alhaddad, CR Göb… - Angewandte Chemie …, 2023 - Wiley Online Library
Levocetirizine is an orally administrated, second‐generation antihistaminic active
pharmaceutical ingredient that has been used to treat symptoms of allergy and long‐term …

Alternating heterochiral supramolecular copolymerization

M Ueda, T Aoki, T Akiyama, T Nakamuro… - Journal of the …, 2021 - ACS Publications
In stacking-based supramolecular polymerization, chiral hydrogen bonding (H-bonding)
monomers often prefer to adapt a homochiral monomer sequence. Herein, we investigated …

Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization

T Sasaki, T Nakane, A Kawamoto, T Nishizawa… - …, 2023 - pubs.rsc.org
Solid-state grinding can provide “mechano-distinctive” co-crystals that are not accessible
from solutions. Herein, we demonstrate the structure determination of a powdered mechano …

B/N-Doped p-Arylenevinylene Chromophores: Synthesis, Properties, and Microcrystal Electron Crystallographic Study

H Lu, T Nakamuro, K Yamashita… - Journal of the …, 2020 - ACS Publications
Linearly conjugated systems have long served as an archetype of conjugated materials, but
suffer from two intrinsic structural problems: potential instability due to intermolecular …

Solid-state NMR spectroscopy for the analysis of element-based non-covalent interactions

Y Xu, PMJ Szell, V Kumar, DL Bryce - Coordination Chemistry Reviews, 2020 - Elsevier
We review applications of solid-state NMR spectroscopy for the analysis of element-based
non-covalent interactions, with an emphasis on developments since 2009. The review is …

[HTML][HTML] Discovering the solid-state secrets of lorlatinib by NMR crystallography: to hydrogen bond or not to hydrogen bond

Z Rehman, WT Franks, B Nguyen, HF Schmidt… - Journal of …, 2023 - Elsevier
Lorlatinib is an active pharmaceutical ingredient (API) used in the treatment of lung cancer.
Here, an NMR crystallography analysis is presented whereby the single-crystal X-ray …

Hemozoin in malaria eradication—from material science, technology to field test

A Rathi, Z Chowdhry, A Patel, S Zuo, TCP Veettil… - NPG Asia …, 2023 - nature.com
Malaria continues to be among the most lethal infectious diseases. Immediate barriers
include the detection of low-parasitemia levels in asymptomatic individuals, which act as a …

[HTML][HTML] Molecular mechanisms of amyloid disaggregation

KJY Low, A Venkatraman, JS Mehta… - Journal of Advanced …, 2022 - Elsevier
Introduction Protein aggregation and deposition of uniformly arranged amyloid fibrils in the
form of plaques or amorphous aggregates is characteristic of amyloid diseases. The …