This review aims to provide an overview of the current knowledge of the genetic lesions
driving pediatric acute myeloid leukemia (AML), emerging biological concepts, and …

Recent studies have provided several insights into acute myeloid leukemia. Studies based
on molecular biology have identified eight functional mutations involved in leukemogenesis …

Abstract Recurring chromosomal translocation t (10; 17)(p15; q21) present in a subset of
human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed …

Simple Summary Transplantation of adult hematopoietic stem cells is an important
therapeutic tool to help patients suffering from diverse hematological disorders. All types of …

Acute myeloid leukemia (AML) is an aggressive, often fatal hematopoietic malignancy. All-
trans retinoic acid (atRA), one of the first molecularly targeted drugs in oncology, has greatly …

The leukemic stem cell (LSC) score LSC-17 based on a stemness–related gene expression
signature is an indicator of poor disease outcome in acute myeloid leukemia (AML) …

A subpopulation of deeply quiescent, so-called dormant hematopoietic stem cells (dHSCs)
resides at the top of the hematopoietic hierarchy and serves as a reserve pool for HSCs. The …

10% of human acute leukemias carry chromosomal translocations involving the mixed
lineage leukemia (MLL) gene that result in the expression of chimeric protein fusing MLL to> …

Inv (11)(p15q23), found in myelodysplastic syndromes and acute myeloid leukemia, leads to
expression of a fusion protein consisting of the N-terminal of nucleoporin 98 (NUP98) and …

Objective There is an unmet need for novel therapies to treat acute myeloid leukemia (AML)
and the associated relapse that involves leukemia stem cells (LSCs). An experimental AML …