The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

Highly ordered organisation of striated muscle is the prerequisite for the fast and
unidirectional development of force and motion during heart and skeletal muscle …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

High molecular weight homologues of gp91 phox, the superoxide-generating subunit of
phagocyte nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, have been …

In striated muscles, the rapid production of macroscopic levels of force and displacement
stems directly from highly ordered and hierarchical protein organization, with the sarcomere …

Myofibrillogenesis in striated muscles is a highly complex process that depends on the
coordinated assembly and integration of a large number of contractile, cytoskeletal, and …

The sarcomere is the basic unit of the myofibrils, which mediate skeletal and cardiac Muscle
contraction. Two transverse structures, the Z-disc and the M-band, anchor the thin (actin and …

Vertebrate-striated muscle is assumed to owe its remarkable order to the molecular ruler
functions of the giant modular signaling proteins, titin and nebulin. It was believed that these …

In C. elegans, mutants that are defective in muscle function and/or structure are easy to
detect and analyze since: 1) body wall muscle is essential for locomotion, and 2) muscle …