Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …

Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …

Uveal melanoma (UM) and retinoblastoma (RB), which cause blindness and even death,
are the most frequently observed primary intraocular malignancies in adults and children …

Liquid biopsy and circulating tumor cell (CTC) screening has gained interest over the last
two decades for detecting almost all solid malignancies. To date, the major limitation in …

Simple Summary Conjunctival melanoma (CM) is a small but highly aggressive and
infiltrative periocular malignancy. Despite wide surgical excision followed by adjuvant …

Background Melanoma is an extremely aggressive type of skin cancer and experiencing a
expeditiously rising mortality in a current year. Exploring new potential prognostic …

The NOTCH signaling system regulates a variety of cellular processes during embryonic
development and homeostasis maintenance in different tissues and contexts. Hence …

Molecular classification based on transcriptional characteristics is often used to study tumor
heterogeneity. Human cancer has different cell populations with distinct transcription in …

Elucidating the cellular and genetic composition of ocular tissues is essential for uncovering
the pathophysiology of ocular diseases. Since the introduction of single-cell RNA …

Melanocytes are located in various parts of the human body, such as the skin and the eye.
Their transformation leads to melanoma, an aggressive and deadly neoplasm. Cutaneous …