Mouse models of SLE have been indispensable tools to study disease pathogenesis, to
identify genetic susceptibility loci and targets for drug development, and for preclinical …

Autoimmune diseases contain a large number of pathologies characterized by various
factors that contribute to a breakdown in self-tolerance. Cytokine-mediated immunity plays …

Chlorogenic acid (CGA) is a phenylpropyl substance synthesized through the shikimic acid
pathway. In addition to its anti-tumor, anti-inflammatory, and antioxidant abilities, CGA also …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of
clinical manifestations and multifactorial etiologies ranging from environmental to genetic …

There is no therapeutic agent approved in cutaneous mastocytosis and mast cell activation
syndrome. We report the efficacy of hydroxychloroquine in four patients with cutaneous …

Background Oral and topical calcineurin inhibitors (CI s) have been reported to lead to
complete lesion remission in several dogs with vesicular cutaneous lupus erythematosus …

Drug repurposing is used to propose new therapeutic perspectives. Here, we introduce
“Drug Upgrade”, that is, characterizing the mode of action of an old drug to generate new …

Mast cells (MCs) distribute to interface tissues with environment, such as skin, airway, and
gut mucosa, thereby functioning as the sentinel against invading allergens and pathogens …

Objective This study explored the predictors of hydroxychloroquine intolerance and propose
appropriate methods to initiate hydroxychloroquine in patients with systemic lupus …

In recent years of immunology, the understanding of innate immunity has deepened, and the
concept of innate immunity has been proposed even in the area of acquired immune …