Acetate revisited: A key biomolecule at the nexus of metabolism, epigenetics and oncogenesis—Part 1: Acetyl-CoA, acetogenesis and acyl-CoA short-chain …

JR Moffett, N Puthillathu, R Vengilote… - Frontiers in …, 2020 - frontiersin.org
Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …

Acetate revisited: a key biomolecule at the nexus of metabolism, epigenetics, and oncogenesis–part 2: acetate and ACSS2 in health and disease

JR Moffett, N Puthillathu, R Vengilote… - Frontiers in …, 2020 - frontiersin.org
Acetate, the shortest chain fatty acid, has been implicated in providing health benefits
whether it is derived from the diet or is generated from microbial fermentation of fiber in the …

N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation

JR Moffett, P Arun, PS Ariyannur… - Frontiers in …, 2013 - frontiersin.org
N-Acetylaspartate (NAA) is employed as a non-invasive marker for neuronal health using
proton magnetic resonance spectroscopy (MRS). This utility is afforded by the fact that NAA …

A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells

SY Huang, W Lu, D Ge, N Meng, Y Li, L Su, SL Zhang… - Autophagy, 2015 - Taylor & Francis
TGFB2-OT1 (TGFB2 overlapping transcript 1) is a newly discovered long noncoding RNA
(lncRNA) derived from the 3′ UTR of TGFB2. It can regulate autophagy in vascular …

[HTML][HTML] In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

SM Jung, WG Doxsey, J Le, JA Haley, L Mazuecos… - Cell reports, 2021 - cell.com
Active brown adipose tissue (BAT) consumes copious amounts of glucose, yet how glucose
metabolism supports thermogenesis is unclear. By combining transcriptomics …

The pathogenesis of, and pharmacological treatment for, Canavan disease

H Wei, JR Moffett, M Amanat, A Fatemi… - Drug Discovery …, 2022 - Elsevier
Highlights•Canavan disease (CD) is an inherited leukodystrophy resulting from mutations in
the ASPA gene.•ASPA deficiency results in severe dysmyelination and a failure of normal …

Ephedra sinica mitigates hepatic oxidative stress and inflammation via suppressing the TLR4/MyD88/NF-κB pathway in fipronil-treated rats

M Seif, M Deabes, A El-Askary, AF El-Kott… - … Science and Pollution …, 2021 - Springer
Ephedra sinica (ES) is a promising medicinal plant with a wide range of pharmacological
aspects, including antioxidant and anti-inflammatory properties. Fipronil (FN) is a popularly …

1,25-Dihydroxyvitamin D3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration

CJ Ricciardi, J Bae, D Esposito, S Komarnytsky… - European journal of …, 2015 - Springer
Purpose The vitamin D system plays a role in metabolism regulation. 1, 25-dihydroxyvitamin
D 3 (1, 25 (OH) 2 D 3) suppressed 3T3-L1 white adipocyte differentiation. Vitamin D receptor …

Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy

G von Jonquieres, ZHT Spencer, BD Rowlands… - Acta …, 2018 - Springer
N-Acetylaspartate (NAA) is the second most abundant organic metabolite in the brain, but its
physiological significance remains enigmatic. Toxic NAA accumulation appears to be the …

Enzymatically Bioactive Nucleus Pulposus Matrix Hydrogel Microspheres for Exogenous Stem Cells Therapy and Endogenous Repair Strategy to Achieve Disc …

Y Peng, X Chen, Q Zhang, S Liu, W Wu, K Li… - Advanced …, 2024 - Wiley Online Library
Exogenous stem cell therapy and endogenous repair has shown great potential in
intervertebral disc regeneration. However, limited nutrients and accumulation of lactate …