Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

The retina has long been regarded as 'an approachable part of the brain'for investigating
neurosensory processes. Cell biologists are now capitalizing on the accessibility of the …

Nuclear receptors are ancient ligand-regulated transcription factors that control key
metabolic and developmental pathways. The fruitfly Drosophila melanogaster has only 18 …

Blood vessels that supply the inner portion of the retina are extensively reorganized during
development. The vessel regression, sprouting angiogenesis, vascular remodelling and …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Multipotent retinal progenitors undergo a varied number of divisions to produce clones of
heterogeneous sizes and cell types. We describe the transition from a proliferating …

Müller glial cells ensheath all retinal neurons in vertebrate retinae. There are a multitude of
functional interactions between neurons and Müller cells, including delivery of the light …

Two fundamental properties of stem cells are their ability to self-renew and to differentiate.
Self-renewal is an integration of proliferation control with the maintenance of an …

In the developing nervous system, the balance between proliferation and differentiation is
critical to generate the appropriate numbers and types of neurons and glia. Notch signaling …

Throughout the central nervous system, astrocytes adopt precisely ordered spatial
arrangements of their somata and arbors, which facilitate their many important functions …