Traumatic brain injury: mechanisms of glial response

RG Mira, M Lira, W Cerpa - Frontiers in physiology, 2021 - frontiersin.org
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …

Cerebral Hypoxia-Induced Molecular Alterations and Their Impact on the Physiology of Neurons and Dendritic Spines: A Comprehensive Review

C Cui, X Jiang, Y Wang, C Li, Z Lin, Y Wei… - Cellular and Molecular …, 2024 - Springer
This article comprehensively reviews how cerebral hypoxia impacts the physiological state
of neurons and dendritic spines through a series of molecular changes, and explores the …

The functional and molecular effects of problematic alcohol consumption on skeletal muscle: A focus on athletic performance

C Caceres-Ayala, RM Pautassi, MJ Acuña… - The American Journal …, 2022 - Taylor & Francis
Background: Chronic alcohol misuse is associated with alcoholic myopathy, characterized
by skeletal muscle weakness and atrophy. Moreover, there is evidence that sports-related …

Therapeutic strategies of small molecules in the microbiota–gut–brain axis for alcohol use disorder

L Xie, W Rungratanawanich, Q Yang, G Tong, E Fu… - Drug discovery today, 2023 - Elsevier
Highlights•MGBA contributes to the pathogenesis associated with AUD.•SCFAs and
peptides in MGBA become therapeutic targets in AUD.•Neurotransmitters affect the brain …

Regulation of Phosphorylated State of NMDA Receptor by STEP61 Phosphatase after Mild-Traumatic Brain Injury: Role of Oxidative Stress

FJ Carvajal, W Cerpa - Antioxidants, 2021 - mdpi.com
Traumatic Brain Injury (TBI) mediates neuronal death through several events involving many
molecular pathways, including the glutamate-mediated excitotoxicity for excessive …

Chemogenetic manipulation of astrocytic signaling in the basolateral amygdala reduces binge‐like alcohol consumption in male mice

KN Nwachukwu, WA Evans, TR Sides… - Journal of …, 2021 - Wiley Online Library
Binge drinking is a common occurrence in the United States, but a high concentration of
alcohol in the blood has been shown to have reinforcing and reciprocal effects on the …

Acetobacter pasteurianus BP2201 alleviates alcohol‐induced hepatic and neuro‐toxicity and modulate gut microbiota in mice

X Wen, Z Wang, Q Liu, DJ Lessing… - Microbial …, 2023 - Wiley Online Library
The excessive consumption of alcohol results in a dysbiosis of the gut microbiota, which
subsequently impairs the gut microbiota‐brain/liver axes and induces cognitive dysfunction …

Cellular bioenergetics: experimental evidence for alcohol-induced adaptations

L Simon, PE Molina - Function, 2022 - academic.oup.com
At-risk alcohol use is associated with multisystemic effects and end-organ injury, and
significantly contributes to global health burden. Several alcohol-mediated mechanisms …

Assessing the joint effects of mitochondrial function and human behavior on the risks of anxiety and depression

H Zhang, Y Chen, J Zhang, Z Zhang, C Pan… - Journal of Affective …, 2023 - Elsevier
Background Psychiatric disorders have great health hazards and the exact pathogeny
remains elusive now. We aim to explore the potential interaction effects of mitochondrial …

Progress in research on the role of clinical nutrition in treating traumatic brain injury affecting the neurovascular unit

JQ Lai, XR Chen, S Lin, CN Chen… - Nutrition Reviews, 2023 - academic.oup.com
The neurovascular unit (NVU) is composed of neurons, glial cells, and blood vessels. NVU
dysfunction involves the processes of neuroinflammation, and microcirculatory disturbances …