Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA
polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical …

Methods to regulate gene expression programs in bacterial cells are limited by the absence
of effective gene activators. To address this challenge, we have developed synthetic …

Phage diversity significantly contributes to ecology and evolution of new bacterial species
through horizontal gene transfer. Therefore, it is essential to understand the mechanisms …

Jumbo phages have attracted much attention by virtue of their extraordinary genome size
and unusual aspects of biology. By performing a comparative genomics analysis of 224 …

By entering a reversible state of reduced metabolic activity, dormant microorganisms are
able to tolerate suboptimal conditions that would otherwise reduce their fitness. Dormancy …

Examples of long-range gene regulation in bacteria are rare and generally thought to
involve DNA looping. Here, using a combination of biophysical approaches including X-ray …

RN ase J1 is the major 5′‐to‐3′ bacterial exoribonuclease. We demonstrate that in its
absence, RNA polymerases (RNAP s) are redistributed on DNA, with increased RNAP …

Transcription activation of bacteriophage T4 late genes is accomplished by a transcription
activation complex containing RNA polymerase (RNAP), the promoter specificity factor gp55 …

The parasitic life cycle of viruses involves the obligatory subversion of the host's
macromolecular processes for efficient viral progeny production. Viruses that infect bacteria …

Transcription of DNA to RNA by DNA-dependent RNA polymerase (RNAP) is the first step of
gene expression and a major regulation point. Bacteriophages hijack their host's …