Persistence and pathogenesis of the neurotropic polyomavirus JC

HS Wollebo, MK White, J Gordon, JR Berger… - Annals of …, 2015 - Wiley Online Library
Many neurological diseases of the central nervous system (CNS) are underpinned by
malfunctions of the immune system, including disorders involving opportunistic infections …

Role of Tat protein in HIV neuropathogenesis

W Li, G Li, J Steiner, A Nath - Neurotoxicity research, 2009 - Springer
The Tat protein of the human immunodeficiency virus (HIV) has been implicated in the
pathophysiology of the neurocognitive deficits associated with HIV infection. This is the …

JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis

MT Pho, A Ashok, WJ Atwood - Journal of virology, 2000 - Am Soc Microbiol
The human polyomavirus JC virus (JCV) is the etiologic agent of a fatal central nervous
system (CNS) demyelinating disease known as progressive multifocal leukoencephalopathy …

Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif

U Neu, MS Maginnis, AS Palma, LJ Ströh… - Cell host & …, 2010 - cell.com
The human JC polyomavirus (JCV) causes a fatal demyelinating disease, progressive
multifocal leukoencephalopathy (PML), in immunocompromised individuals. Current …

Identification and characterization of mefloquine efficacy against JC virus in vitro

M Brickelmaier, A Lugovskoy… - Antimicrobial agents …, 2009 - Am Soc Microbiol
Progressive multifocal leukoencephalopathy (PML) is a rare but frequently fatal disease
caused by the uncontrolled replication of JC virus (JCV), a polyomavirus, in the brains of …

JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor

BA O'Hara, J Morris-Love, GV Gee, SA Haley… - PLoS …, 2020 - journals.plos.org
The human polyomavirus, JCPyV, is the causative agent of progressive multifocal
leukoencephalopathy (PML) in immunosuppressed and immunomodulated patients. Initial …

JC polyomavirus uses extracellular vesicles to infect target cells

J Morris-Love, GV Gee, BA O'Hara, B Assetta… - MBio, 2019 - Am Soc Microbiol
The endemic human JC polyomavirus (JCPyV) causes progressive multifocal
leukoencephalopathy in immune-suppressed patients. The mechanisms of virus infection in …

Infection of glial cells by the human polyomavirus JC is mediated by an N-linked glycoprotein containing terminal α (2-6)-linked sialic acids

CK Liu, G Wei, WJ Atwood - Journal of virology, 1998 - Am Soc Microbiol
The human JC polyomavirus (JCV) is the etiologic agent of the fatal central nervous system
(CNS) demyelinating disease progressive multifocal leukoencephalopathy (PML). PML …

Decreased function of survival motor neuron protein impairs endocytic pathways

M Dimitriadi, A Derdowski, G Kalloo… - Proceedings of the …, 2016 - National Acad Sciences
Spinal muscular atrophy (SMA) is caused by depletion of the ubiquitously expressed
survival motor neuron (SMN) protein, with 1 in 40 Caucasians being heterozygous for a …

Contrasting roles of endosomal pH and the cytoskeleton in infection of human glial cells by JC virus and simian virus 40

A Ashok, WJ Atwood - Journal of virology, 2003 - Am Soc Microbiol
Infection of eukaryotic cells by pathogens requires the efficient use of host cell endocytic and
cytoplasmic transport mechanisms. Understanding how these cellular functions are …