Mechanism and treatment of α-amanitin poisoning

J Xue, X Lou, D Ning, R Shao, G Chen - Archives of toxicology, 2023 - Springer
Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main
lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment …

Amatoxin poisoning: case reports and review of current therapies

J Ward, K Kapadia, E Brush, SD Salhanick - The Journal of emergency …, 2013 - Elsevier
BACKGROUND: Diagnosis and management of Amanita mushroom poisoning is a
challenging problem for physicians across the United States. With 5902 mushroom …

Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial

MW Fried, VJ Navarro, N Afdhal, SH Belle, AS Wahed… - Jama, 2012 - jamanetwork.com
Context The botanical product silymarin, an extract of milk thistle, is commonly used by
patients to treat chronic liver disease, despite scant and conflicting evidence of its efficacy …

Mycetism: a review of the recent literature

KA Graeme - Journal of Medical Toxicology, 2014 - Springer
Approximately 100 of the known species of mushrooms are poisonous to humans. New toxic
mushroom species continue to be identified. Some species initially classified as edible are …

N-acetylcysteine as a treatment for amatoxin poisoning: a systematic review

J Liu, Y Chen, Y Gao, JH Walline, X Lu, S Yu… - Clinical …, 2020 - Taylor & Francis
Introduction: Amatoxin leads to the majority of deaths by mushroom poisoning around the
world. Amatoxin causes gastrointestinal disturbances and multiple organ dysfunction …

In vivo and in vitro α-amanitin metabolism studies using molecular networking

B Le Daré, PJ Ferron, A Couette, C Ribault, I Morel… - Toxicology Letters, 2021 - Elsevier
Amanitin poisonings are among the most life-threatening mushroom poisonings, and are
mainly caused by the genus Amanita. Hepatotoxicity is the hallmark of amanitins, powerful …

Hepatoprotective Effects and Mechanisms of Action of Triterpenoids from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on α-Amanitin …

H Wu, S Tang, Z Huang, Q Zhou… - … journal of medicinal …, 2016 - dl.begellhouse.com
Most fatal mushroom poisonings are caused by species of the genus Amanita; the
amatoxins are responsible for acute liver failure and death in humans. Ganoderma lucidum …

Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2

H Wang, G Yang, X Zhang, H Zhang, Y Liu… - Food and Chemical …, 2023 - Elsevier
Abstract α-Amanitin, the primary lethal toxin of Amanita, specifically targets the liver, causing
oxidative stress, hepatocyte apoptosis, and irreversible liver damage. As little as 0.1 mg/kg …

Amatoxin and phallotoxin concentration in Amanita phalloides spores and tissues

E Kaya, S Karahan, R Bayram… - Toxicology and …, 2015 - journals.sagepub.com
Most of the fatal cases of mushroom poisoning are caused by Amanita phalloides. The
amount of toxin in mushroom varies according to climate and environmental conditions. The …

Hepatoprotective Effects of Aqueous Extract from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) on α-Amanitin−Induced Liver …

X Wu, J Zeng, J Hu, Q Liao, R Zhou… - … journal of medicinal …, 2013 - dl.begellhouse.com
ABSTRACT The Lingzhi or Reishi mushroom Ganoderma lucidum is a well-known
traditional medicinal mushroom that has been shown to have obvious hepatoprotective …