MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

The multistep process of cancer progresses over many years. The prevention of mutations
by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance …

It is well established that ferroptosis is primarily controlled by glutathione peroxidase 4
(GPX4). Surprisingly, we observed that p53 activation modulates ferroptotic responses …

Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein
p53 (TP53) are missense mutations,. Mutant p53 protein is often abundantly expressed in …

Triple-negative breast cancers (TNBC) frequently inactivate p53, increasing their
aggressiveness and therapy resistance. We identified an unexpected protein vulnerability in …

Abstract p53 is a crucial tumour suppressor that responds to diverse stress signals by
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …

The tumour suppressor TP53 is a master regulator of several cellular processes that
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

Selective targeting of BCL-2 with the BH3-mimetic venetoclax has been a transformative
treatment for patients with various leukemias. TP-53 controls apoptosis upstream of where …

The fundamental biological importance of the Tp53 gene family is highlighted by its
evolutionary conservation for more than one billion years dating back to the earliest …