Since the original identification of the T helper 17 (Th17) subset in 2005, it has become
evident that these cells do not only contribute to host defence against pathogens, such as …

Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …

Human immunodeficiency virus (HIV) persistence during antiretroviral therapy (ART) is
associated with heightened plasma interleukin-10 (IL-10) levels and PD-1 expression. We …

HIV-1 infection is associated with substantial damage to the gastrointestinal tract resulting in
structural impairment of the epithelial barrier and a disruption of intestinal homeostasis. The …

Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to
regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV …

Objectives: The objective of this article is to investigate the contribution of colon and blood
CD4+ T-cell subsets expressing the chemokine receptor CCR6 to HIV persistence during …

The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector
functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and …

Background Th17 cells are permissive to HIV-1 infection and their depletion from the gut of
infected individuals leads to microbial translocation, a major cause for non-AIDS co …

Th17 cells are enriched in the gut mucosa and play a critical role in maintenance of the
mucosal barrier and host defense against extracellular bacteria and fungal infections …

Despite successful control of viremia, many HIV-infected individuals given antiretroviral
therapy (ART) exhibit residual inflammation, which is associated with non–AIDS-related …