Chordoma is a rare, but often malignant, bone cancer that preferentially affects the axial
skeleton and the skull base. These tumors are both sporadic and hereditary and appear to …

Chordoma is a rare low-grade primary malignant skeletal tumor, which is presumed to
derive from notochord remnants. The pathogenesis of chordoma has not been fully …

Chordoma, a rare bone tumor derived from the notochord, has been shown to be resistant to
conventional therapies. Checkpoint inhibition has shown great promise in immune-mediated …

Skull base chordoma (SBC) is a bone cancer with a high recurrence rate, high
radioresistance rate, and poorly understood mechanism. Here, we profiled the …

PURPOSE: The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase
is overexpressed in various tumors and has been linked to poor prognosis. Its role as proto …

Sarcoma, the second common type of solid tumor in children and adolescents, has a wide
variety of subtypes that are often not properly diagnosed at an early stage, leading to late …

Purpose: Conventional chemotherapeutic agents are ineffective in the treatment of
chordoma. We investigated the functional roles and therapeutic relevance of the sex …

Soft tissue chordomas (STCs) have never been systematically studied because of their rarity
and the difficulty in separating them from similar-appearing lesions. Using brachyury to …

Chordomas are rare bone tumors arising from remnants of the notochord. Molecular studies
to determine the pathways involved in their pathogenesis and develop better treatments are …

Chordomas are one of the rarest bone tumors, and they originate from remnants of
embryonic notochord along the spine, more frequently at the skull base and sacrum …