Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation

A Bataille, SD Cashins, L Grogan… - … of the Royal …, 2015 - royalsocietypublishing.org
The pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd) can cause precipitous
population declines in its amphibian hosts. Responses of individuals to infection vary greatly …

The Amphibian Major Histocompatibility Complex—A Review and Future Outlook

J Sabino-Pinto, ME Maan - Journal of Molecular Evolution, 2025 - Springer
The major histocompatibility complex (MHC) is a cluster of functionally related genes
encoding proteins which, among other functions, mediate immune system activation. While …

Major Histocompatibility Complex Variation and Haplotype Associated Survival in Response to Experimental Infection of Two Bd-GPL Strains Along a Latitudinal …

M Cortazar-Chinarro, S Meurling… - Frontiers in Ecology …, 2022 - frontiersin.org
While both innate and adaptive immune system mechanisms have been implicated in
resistance against the chytrid fungus Batrachochytrium dendrobatidis (Bd), studies on the …

Signatures of historical selection on MHC reveal different selection patterns in the moor frog (Rana arvalis)

M Cortazar-Chinarro, Y Meyer-Lucht, A Laurila… - Immunogenetics, 2018 - Springer
MHC genes are key components in disease resistance and an excellent system for studying
selection acting on genetic variation in natural populations. Current patterns of variation in …

Limited evidence for genetic differentiation or adaptation in two amphibian species across replicated rural–urban gradients

W Babik, M Marszałek, K Dudek… - Evolutionary …, 2024 - Wiley Online Library
Urbanization leads to complex environmental changes and poses multiple challenges to
organisms. Amphibians are highly susceptible to the effects of urbanization, with land use …

Drift Rather than Selection Dominates MHC Class II Allelic Diversity Patterns at the Biogeographical Range Scale in Natterjack Toads Bufo calamita

I Zeisset, TJC Beebee - PLoS One, 2014 - journals.plos.org
Study of major histocompatibility complex (MHC) loci has gained great popularity in recent
years, partly due to their function in protecting vertebrates from infections. This is of particular …

Genetic drift shaped MHC IIB diversity of an endangered anuran species within the Italian glacial refugium

L Talarico, W Babik, S Marta, M Mattoccia - Journal of Zoology, 2019 - Wiley Online Library
Highly polymorphic genes of the major histocompatibility complex (MHC) encode proteins
involved in the immune response that protect vertebrates from parasites and pathogen …

Molecular characterization of MHC class II in the Australian invasive cane toad reveals multiple splice variants

M Lillie, J Cui, R Shine, K Belov - Immunogenetics, 2016 - Springer
The cane toad has gained notoriety for its invasion across the Australian landscape, with
significant impacts on the native Australian fauna. The invasion has accelerated over time …

Low MHC variation in isolated island populations of the Natterjack toad (Bufo calamita)

J Höglund, Å Wengström, B Rogell… - Conservation genetics, 2015 - Springer
We studied variation at the class II gene of the major histocompatibility complex (MHC) in
Natterjack toad populations (Bufo [Epidalea] calamita) on islands off the west coast of …

Latitudinal MHC variation and haplotype associated differential survival in response to experimental infection of two strains of Batrachochytrium dendrobatitis (Bd …

M Cortazar-Chinarro, S Meurling, L Schroyens… - Biorxiv, 2019 - biorxiv.org
While both innate and adaptive immune system mechanisms have been implicated in
resistance against the chytrid fungus Batrachochytrium dendrobatitis, studies on the role of …