Background With the rise of artificial intelligence (AI) in the field of dementia biomarker
research, exploring its current developmental trends and research focuses has become …

The process of identification and management of neurological disorder conditions faces
challenges, prompting the investigation of novel methods in order to improve diagnostic …

Objective To identify potential biomarkers of preclinical and clinical progression in
chromosome 9 open reading frame 72 gene (C9orf72)-associated disease by assessing the …

Background Amyotrophic lateral sclerosis (ALS) is a rare progressive neurodegenerative
disease that affects upper and lower motor neurons. As the molecular basis of the disease is …

Background and purpose The antisense oligonucleotide nusinersen (Spinraza) regulates
splicing of the survival motor neuron 2 (SMN2) messenger RNA to increase SMN protein …

Abstract The RNAse III DICER is essential for miRNA biogenesis. DICER activity is
downregulated in sporadic and genetic forms of ALS. Accordingly, hundreds of miRNAs are …

The observation that aging is regulated by microRNAs (miRNA) and at the same time
represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the …

Frontotemporal dementia is a debilitating neurodegenerative disorder characterized by
frontal and temporal lobe degeneration, resulting in behavioral changes, language …

Abstract microRNAs (miRNAs) are small noncoding RNAs that regulate mRNA stability
and/or protein biosynthesis and, therefore, gene expression. They have been studied and …

Frontotemporal dementia (FTD) represents the second most common type of dementia in
adults under the age of 65. Currently, there are no treatments that can cure this condition. In …