Highlights•RS establishes itself as a leading technology for monitoring and control of
CPPs.•The technology shows promise in measuring cell type and differentiation of …

Continuous biopharmaceutical manufacturing is currently a field of intense research due to
its potential to make the entire production process more optimal for the modern, ever …

The biopharmaceutical industry extensively employs Chinese hamster ovary (CHO) cell
culture for monoclonal antibody production. Amino acids represent an essential source of …

Raman spectroscopy coupled to chemometric model-based technology have a great
potential for real-time monitoring of critical process parameters in animal cell culture. The …

A novel approach of design of experiment (DoE) is developed for the optimization of key
substrates of the culture medium, amino acids, and sugars, by utilizing perfusion …

As the biopharmaceutical industry looks to implement Industry 4.0, the need for rapid and
robust analytical characterization of analytes has become a pressing priority. Spectroscopic …

Advanced process control in the biopharmaceutical industry often lacks real‐time
measurements due to resource constraints. Raman spectroscopy and Partial Least Squares …

The development of optical sensors for label-free quantification of cell parameters has
numerous uses in the biomedical arena. However, using current optical probes requires the …

To enhance the robustness and flexibility of biopharmaceutical manufacturing, a paradigm
shift toward methods of continuous processing, such as perfusion, and fundamental …

As a non‐destructive sensing technique, Raman spectroscopy is often combined with
regression models for real‐time detection of key components in microbial cultivation …