Preparation and characterization of hexaconazole/hydroxypropyl-gamma-cyclodextrin inclusion complex nanofibers for sustainable agriculture: improved …

B Liu, J Duan, Y Zhang, R Wang, L Zhao, S Gao… - Journal of Molecular …, 2024 - Elsevier
Hexaconazole (HEZ) is a triazole fungicide with low water solubility, which restricts its use in
agricultural production. In this work, HEZ/hydroxypropyl-γ-cyclodextrin inclusion complex …

Novel Insights into Stereoselective Reproductive Toxicity Induced by Mefentrifluconazole in Earthworms (Eisenia fetida): First Report of Estrogenic Effects

X Yao, H Lv, Q Wang, J Ding, W Kong… - Journal of Agricultural …, 2024 - ACS Publications
Widespread use of the new chiral triazole fungicide mefentrifluconazole (MFZ) poses a
threat to soil organisms. Although triazole fungicides have been reported to induce …

A realistic mixture of ubiquitous persistent organic pollutants affects bone and cartilage development in zebrafish by interaction with nuclear receptor signaling

G Guerrero-Limón, J Zappia, M Muller - Plos one, 2024 - journals.plos.org
" Persistent organic pollutants (POPs)" have a plethora of deleterious effects on humans and
the environment due to their bioaccumulative, persistent, and mimicking properties …

Enantioselective toxicity effect and mechanism of hexaconazole enantiomers to human breast cancer cells

N Yang, J Pang, Z Huang, Q Zhang, Z Wang… - Food and Chemical …, 2023 - Elsevier
The toxicity effects of chiral pesticides on living organisms have attracted an increasing
public attention. This study aims to investigate the toxicity effect and mechanism of …

Sub-chronic exposure to hexaconazole affects the lipid metabolism of rats through mTOR-PPAR-γ/SREBP1 signaling pathway mediated by oxidative stress

D Sun, G Luo, Q Zhang, M Wang, T Yang… - Pesticide Biochemistry …, 2023 - Elsevier
Hexaconazole (Hex) is a widely used and high frequency detected triazole fungicide in
agricultural products and environment which may pose potential toxicity to the nontargeted …

Potency of hexaconazole to disrupt endocrine function with sex hormone-binding globulin

A Alquraini - International Journal of Molecular Sciences, 2023 - mdpi.com
Hexaconazole is widely used as a fungicide for agricultural purposes. However, the
endocrine-disrupting potential of hexaconazole is still under investigation. In addition, an …

Identification of potential chemical biomarkers of hexaconazole using in vitro metabolite profiling in rat and human liver microsomes and in vivo confirmation through …

C Yahavi, A Pandey, M Bhateria, BV Warkad… - Chemosphere, 2024 - Elsevier
Hexaconazole (HEX) is an azole fungicide widely used in agricultural practices across
various countries and numerous studies have reported the toxic effects of HEX, such as …

Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment

SAH Abdi, A Ali, S Fatma Sayed, A Ali… - Toxicology …, 2023 - Taylor & Francis
Paracetamol is generally recommended for pain and fever. However, as per experimental
and epidemiological data, widespread and irrational or long-term use of paracetamol may …

Hexaconazole exposure may lead to Parkinson via disrupting glucocerebrosidase and parkin: molecular interaction, dynamics, MMPBSA and DFT based in-silico …

FK Alkholifi, SAH Abdi, M Qadri, SF Sayed… - Toxicology …, 2024 - academic.oup.com
Hexaconazole is a known fungicide for agricultural purposes. It has bioaccumulation ability
which makes it important for its toxicological characterization. There are various neurological …

Investigating the link between microplastic exposure (benzyl butyl phthalate) and neurodegenerative diseases using high-performance computational toxicology

A Abdulrahman - Toxicology Research, 2025 - academic.oup.com
Background Microplastics are tiny plastic particles, typically less than 5 mm in size, formed
from the breakdown of larger plastic products. This breakdown releases additives, including …