Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• CYP2C19 polymorphisms may have
clinical consequences in relation to drugs extensively metabolized by the enzyme.• Recently …

Purpose Voriconazole, an antifungal drug, is metabolized by a cytochrome P450 isozyme.
Increased adverse effects are observed in Asians because of the high rate of poor …

The present study evaluates the worldwide frequency distribution of CYP2C19 alleles and
CYP2C19 metabolic phenotypes ('predicted'from genotypes and 'measured'with a probe …

The advent of high‐throughput technologies has proven valuable in the assessment of
genetic differences and their effects on drug activation, metabolism, disposition, and …

Genetic diversity is greater in Africa than in other continental populations. Genetic variability
in genes encoding drug metabolizing enzymes may contribute to the high numbers of …

What is known and objective Genetic polymorphism is one of the most important factors
responsible for interindividual and interethnic variability in drug response. Studies in major …

The interpretation of genomic variants has become one of the paramount challenges in the
post-genome sequencing era. In this review we summarize nearly 20 years of research on …

Mavacamten is the first and only cardiac myosin inhibitor approved in 5 continents for the
treatment of adults with symptomatic New York Heart Association class II and III obstructive …