Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …

The vascular smooth muscle cell (SMC) in adult animals is a highly specialized cell whose
principal function is contraction. However, this cell displays remarkable plasticity and can …

e160 Arterioscler Thromb Vasc Biol September 2018 were actively exported to the
cytoplasm with exportin-5 in a Ran-GTP–dependent manner. In the cytoplasm, the transition …

Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Identification and treatment of abdominal aortic aneurysm (AAA) remains among the most
prominent challenges in vascular medicine. MicroRNAs are crucial regulators of …

MicroRNAs are short noncoding RNAs, expressed in humans and involved in sequence-
specific post-transcriptional regulation of gene expression. They have emerged as key …

The phenotype of vascular smooth muscle cells (VSMCs) is dynamically regulated in
response to various stimuli. In a cellular process known as phenotype switching, VSMCs …

Rationale: The rapid induction and orchestration of new blood vessels are critical for tissue
repair in response to injury, such as myocardial infarction, and for physiological angiogenic …