The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective

G Williamson, CD Kay, A Crozier - Comprehensive Reviews in …, 2018 - Wiley Online Library
Flavonoids are plant‐derived dietary components with a substantial impact on human
health. Research has expanded massively since it began in the 1930s, and the complex …

Bioavailability of bioactive food compounds: A challenging journey to bioefficacy

MJ Rein, M Renouf, C Cruz‐Hernandez… - British journal of …, 2013 - Wiley Online Library
Bioavailability is a key step in ensuring bioefficacy of bioactive food compounds or oral
drugs. Bioavailability is a complex process involving several different stages: liberation …

Hypothalamic detection of macronutrients via multiple gut-brain pathways

N Goldstein, AD McKnight, JRE Carty, M Arnold… - Cell metabolism, 2021 - cell.com
Food intake is tightly regulated by complex and coordinated gut-brain interactions. Nutrients
rapidly modulate activity in key populations of hypothalamic neurons that regulate food …

Anthocyanins and flavanones are more bioavailable than previously perceived: A review of recent evidence

CD Kay, G Pereira-Caro, IA Ludwig… - Annual Review of …, 2017 - annualreviews.org
This review considers recent investigations on the bioavailability of anthocyanins and
flavanones. Both flavonoids are significant dietary components and are considered to be …

Human pancreatic exocrine response to nutrients in health and disease

J Keller, P Layer - Gut, 2005 - gut.bmj.com
2.1 Introduction The healthy human pancreas adopts exocrine secretion to nutrient ingestion
and there are numerous studies investigating pancreatic exocrine response to various …

Ileal brake: a sensible food target for appetite control. A review

PWJ Maljaars, HPF Peters, DJ Mela, AAM Masclee - Physiology & behavior, 2008 - Elsevier
With the rising prevalence of obesity and related health problems increases, there is
increased interest in the gastrointestinal system as a possible target for pharmacological or …

Fat-induced heal brake in humans: a dose-dependent phenomenon correlated to the plasma levels of peptide YY

L Pironi, V Stanghellini, M Miglioli, R Corinaldesi… - Gastroenterology, 1993 - Elsevier
Background: Upper gastrointestinal motility is reguated by the presence of nutrients in the
distal gut. The present study evaluated whether lipid-induced ileal brake on gastric empting …

Inhibition of gastric emptying by glucose depends on length of intestine exposed to nutrient

HC Lin, JE Doty, TJ Reedy… - American Journal of …, 1989 - journals.physiology.org
Nutrients inhibit gastric emptying in a dose-related fashion. We postulated that load-
dependent gastric emptying results from the saturation of mucosal absorptive mechanisms …

Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt

W Mullen, MA Archeveque, CA Edwards… - Journal of Agricultural …, 2008 - ACS Publications
The bioavailability of dietary phytochemicals may be influenced by the food matrix in which
they are consumed. In this study the impact of a full-fat yogurt on the bioavailability and …

Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults

G Borges, RY Fong, JL Ensunsa, J Kimball… - Free Radical Biology …, 2022 - Elsevier
The bioavailability of apigenin and its O-glycosides in humans was investigated with
apigenin-4′-glucuronide (Ap-4′-GlcUA), apigenin-7-glucuronide and apigenin-7-sulfate …