Detecting genomic islands using bioinformatics approaches

MGI Langille, WWL Hsiao, FSL Brinkman - Nature Reviews …, 2010 - nature.com
Bacterial genomes contain clusters of genes that are acquired by horizontal transfer, called
genomic islands (GIs). GIs are frequently associated with microbial adaptations that are of …

Bacterial repetitive extragenic palindromic sequences are DNA targets for insertion sequence elements

R Tobes, E Pareja - BMC genomics, 2006 - Springer
Background Mobile elements are involved in genomic rearrangements and virulence
acquisition, and hence, are important elements in bacterial genome evolution. The insertion …

Characterization of the core and accessory genomes of Pseudomonas aeruginosa using bioinformatic tools Spine and AGEnt

EA Ozer, JP Allen, AR Hauser - BMC genomics, 2014 - Springer
Background Pseudomonas aeruginosa is an important opportunistic pathogen responsible
for many infections in hospitalized and immunocompromised patients. Previous reports …

IslandViewer: an integrated interface for computational identification and visualization of genomic islands

MGI Langille, FSL Brinkman - Bioinformatics, 2009 - academic.oup.com
Genomic islands (clusters of genes of probable horizontal origin; GIs) play a critical role in
medically important adaptations of bacteria. Recently, several computational methods have …

Pan-genome sequence analysis using Panseq: an online tool for the rapid analysis of core and accessory genomic regions

C Laing, C Buchanan, EN Taboada, Y Zhang… - BMC …, 2010 - Springer
Background The pan-genome of a bacterial species consists of a core and an accessory
gene pool. The accessory genome is thought to be an important source of genetic variability …

Evaluation of genomic island predictors using a comparative genomics approach

MGI Langille, WWL Hsiao, FSL Brinkman - BMC bioinformatics, 2008 - Springer
Abstract Background Genomic islands (GIs) are clusters of genes in prokaryotic genomes of
probable horizontal origin. GIs are disproportionately associated with microbial adaptations …

Improved genomic island predictions with IslandPath-DIMOB

C Bertelli, FSL Brinkman - Bioinformatics, 2018 - academic.oup.com
Abstract Motivation Genomic islands (GIs) are clusters of genes of probable horizontal origin
that play a major role in bacterial and archaeal genome evolution and microbial adaptability …

A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation

T Geissmann, C Chevalier, MJ Cros… - Nucleic acids …, 2009 - academic.oup.com
Bioinformatic analysis of the intergenic regions of Staphylococcus aureus predicted multiple
regulatory regions. From this analysis, we characterized 11 novel noncoding RNAs (RsaA …

A genomic distance based on MUM indicates discontinuity between most bacterial species and genera

M Deloger, M El Karoui, MA Petit - Journal of bacteriology, 2009 - Am Soc Microbiol
The fundamental unit of biological diversity is the species. However, a remarkable extent of
intraspecies diversity in bacteria was discovered by genome sequencing, and it reveals the …

Genomic Island Prediction via Chi‐Square Test and Random Forest Algorithm

M Onesime, Z Yang, Q Dai - Computational and Mathematical …, 2021 - Wiley Online Library
Genomic islands are related to microbial adaptation and carry different genomic
characteristics from the host. Therefore, many methods have been proposed to detect …