Background: The formation of distant metastases constitutes a complex process with a
variety of different genes and pathways involved. To improve patient survival, it is necessary …

Abnormal lipid metabolism including synthesis, uptake, modification, degradation and
transport has been considered a hallmark of malignant tumors and contributes to the supply …

SOX2 was reported to promote metastasis in various tumor tissues; however the underlying
mechanisms remain elusive. Here, we disclosed that SOX2 improves metastasis of breast …

Abnormal expression of long non-coding RNA (lncRNAs) often contributes to unrestricted
growth and invasion of cancer cells. LncRNA XIST expression is up-regulated in several …

Background Trastuzumab, a humanized antibody targeting HER2, exhibits remarkable
therapeutic efficacy against HER2-positive gastric cancer. However, recurrent therapeutic …

MicroRNAs (miRNAs) are involved in the epithelial-mesenchymal transition (EMT) process
and are associated with metastasis in gastric cancer (GC). MiR-338-3p has been reported to …

Introduction: The metastatic dissemination of primary tumors is directly linked to patient
survival in many tumor entities. The previously undescribed gene metastasis-associated in …

Background & Aims: To investigate the expression and prognostic value of MACC1 in
patients with HCC and identify the mechanism by which MACC1 inhibits HCC cell apoptosis …

Although induction of ferroptosis and inhibition of transforming growth factor‐β (TGF‐β)
signaling are both effective ways to reform the tumor microenvironment (TME) and render …

Metastasis associated in colon cancer-1 (MACC1) is a newly identified oncogene, and
increasing evidence has suggested that its overexpression is associated with the …