Transcriptome alterations caused by social defeat stress of various durations in mice and its relevance to depression and posttraumatic stress disorder in humans: A …

VV Reshetnikov, PE Kisaretova, NP Bondar - International journal of …, 2022 - mdpi.com
The research on molecular causes of stress-associated psychopathologies is becoming
highly important because the number of people with depression, generalized anxiety …

[HTML][HTML] Translational models of stress and resilience: An applied neuroscience methodology review

ZS Albayrak, A Vaz, J Bordes, S Ünlü, MSC Sep… - Neuroscience …, 2024 - Elsevier
Stress, encompassing psychological, physical, and physiological challenges, is an important
factor affecting an individual's well-being and potentially leading to psychiatric …

An entorhinal-visual cortical circuit regulates depression-like behaviors

J Lu, Z Zhang, X Yin, Y Tang, R Ji, H Chen… - Molecular …, 2022 - nature.com
Major depressive disorder is viewed as a 'circuitopathy'. The hippocampal-entorhinal
network plays a pivotal role in regulation of depression, and its main sensory output, the …

Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress

D Murra, KL Hilde, A Fitzpatrick, PM Maras… - Neurobiology of …, 2022 - Elsevier
Evaluating and coping with stressful social events as they unfold is a critical strategy in
overcoming them without long-lasting detrimental effects. Individuals display a wide range of …

Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility

A Zhukovskaya, CA Zimmerman, L Willmore… - Neuron, 2024 - cell.com
Some individuals are susceptible to chronic stress, and others are more resilient. While
many brain regions implicated in learning are dysregulated after stress, little is known about …

Tryptophan metabolism as bridge between gut microbiota and brain in chronic social defeat stress-induced depression mice

J Xie, W Wu, J Chen, Q Zhong, D Wu, L Niu… - Frontiers in Cellular …, 2023 - frontiersin.org
Backgrounds Gut microbiota plays a critical role in the onset and development of
depression, but the underlying molecular mechanisms are unclear. This study was …

Altered fecal metabolites and colonic glycerophospholipids were associated with abnormal composition of gut microbiota in a depression model of mice

X Gong, C Huang, X Yang, J Chen, J Pu… - Frontiers in …, 2021 - frontiersin.org
The microbiota–gut–brain axis has been considered to play an important role in the
development of depression, but the underlying mechanism remains unclear. The …

Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice

M Hasegawa, K Piriyaprasath, M Otake… - European Journal of …, 2022 - Wiley Online Library
We investigated the effects of social defeat stress (SDS) and treadmill running on masseter
muscle nociception, which was quantified by the orofacial formalin test and c‐Fos and FosB …

Reward enhances resilience to chronic social defeat stress in mice: Neural ECs and mGluR5 mechanism via neuroprotection in VTA and DRN

P Shi, L Hu, H Ren, Q Dai - Frontiers in Psychiatry, 2023 - frontiersin.org
Introduction Stress often leads to emotional disorders such as depression. The reward might
render this effect through the enhancement of stress resilience. However, the effect of …

Lycopene Alleviates Depression‐Like Behavior in Chronic Social Defeat Stress‐Induced Mice by Promoting Synaptic Plasticity via the BDNF–T rk B Pathway

H Xu, Y Wang, D Geng, F Chen, Y Chen… - Food Science & …, 2025 - Wiley Online Library
Lycopene is a natural plant extract widely studied for its powerful antioxidant and
neuroprotective effects. Emerging evidence suggests that it also possesses potential …