Rational design of polymeric micelles for targeted therapeutic delivery

Y Zheng, Y Oz, Y Gu, N Ahamad, K Shariati… - Nano Today, 2024 - Elsevier
Polymeric micellar drug carriers have emerged as effective tools to enhance the solubility
and bioavailability of hydrophobic drugs. These micelles possess a nano size structure that …

Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: an integrated protocol

AR Crowe, W Yue - Bio-protocol, 2019 - bio-protocol.org
Semi-quantitative IHC is a powerful method for investigating protein expression and
localization within tissues. The semi-quantitative immunohistochemistry (IHC) involves using …

Recent approaches towards the development of ru (II) polypyridyl complexes for anticancer photodynamic therapy

A Gandosio, K Purkait, G Gasser - Chimia, 2021 - chimia.ch
Photodynamic therapy (PDT) is a remarkable alternative or complementary technique to
chemotherapy, radiotherapy or immunotherapy to treat certain forms of cancer. The …

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity

V Laurent, A Guérard, C Mazerolles… - Nature …, 2016 - nature.com
Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic
adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from …

Curcumin-loaded chitosan nanoparticles alleviate fenpropathrin-induced hepatotoxicity by regulating lipogenesis and pyroptosis in rats

LS Alqahtani, YM Abd-Elhakim, AAR Mohamed… - Food and Chemical …, 2023 - Elsevier
In this study, the probable alleviative role of curcumin (CMN)(50 mg/kg b. wt) or curcumin-
loaded chitosan nanoparticle (CLC-NP)(50 mg/kg b. wt) was assessed against the …

The potential ameliorative impacts of cerium oxide nanoparticles against fipronil-induced hepatic steatosis

L Wasef, AMK Nassar, YS El-Sayed, D Samak… - Scientific reports, 2021 - nature.com
Fipronil (FIP) is a phenylpyrazole insecticide that is commonly used in agricultural and
veterinary fields for controlling a wide range of insects, but it is a strong environmentally toxic …

Enhancement of biochemical and genomic pathways through lycopene-loaded nano-liposomes: Alleviating insulin resistance, hepatic steatosis, and autophagy in …

GA Salem, AAR Mohamed, SI Khater, AE Noreldin… - Gene, 2023 - Elsevier
Non-alcoholic fatty liver (NAFL) is a prevalent hepatic disorder of global significance that can
give rise to severe complications. This research endeavor delves into the potential of nano …

Quercetin attenuates pancreatic and renal D-galactose-induced aging-related oxidative alterations in rats

AH El-Far, MA Lebda, AE Noreldin, MS Atta… - International Journal of …, 2020 - mdpi.com
Aging is an oxidative stress-associated process that progresses with age. Our aim is to delay
or attenuate these oxidative alterations and to keep individuals healthy as they age using …

Hepatorenal protective effects of taurine and N-acetylcysteine against fipronil-induced injuries: the antioxidant status and apoptotic markers expression in rats

MM Abdel-Daim, AA Dessouki… - Science of the total …, 2019 - Elsevier
Fipronil (FPN), a commonly used phenylpyrazole pesticide can induce oxidative tissue
damage following hazard usage. Due to the extensive household and commercial usage of …

Withametelin, a steroidal lactone, isolated from datura innoxa attenuates STZ-induced diabetic neuropathic pain in rats through inhibition of NF-kB/MAPK signaling

A Khan, B Shal, AU Khan, MW Baig, I Ul Haq… - Food and Chemical …, 2023 - Elsevier
Diabetic neuropathic pain is one of the microvascular complications of diabetes mellitus
characterized by symmetrical pain and sensory abnormalities. A steroidal lactone isolated …