[HTML][HTML] HIF-1α inhibition improves anti-tumor immunity and promotes the efficacy of stereotactic ablative radiotherapy (SABR)

CW Song, H Kim, H Cho, MS Kim, SH Paek, HJ Park… - Cancers, 2022 - mdpi.com
Simple Summary Stereotactic ablative radiotherapy (SABR), which irradiates tumors with
high-dose radiation per fraction, promotes anti-tumor immunity by stimulating various …

[HTML][HTML] Dual-agent photodynamic therapy with optical clearing eradicates pigmented melanoma in preclinical tumor models

L Pires, V Demidov, BC Wilson, AG Salvio, L Moriyama… - Cancers, 2020 - mdpi.com
Treatment using light-activated photosensitizers (photodynamic therapy, PDT) has shown
limited efficacy in pigmented melanoma, mainly due to the poor penetration of light in this …

Generalized additive models to analyze nonlinear trends in biomedical longitudinal data using R: Beyond repeated measures ANOVA and linear mixed models

AI Mundo, JR Tipton, TJ Muldoon - Statistics in medicine, 2022 - Wiley Online Library
In biomedical research, the outcome of longitudinal studies has been traditionally analyzed
using the repeated measures analysis of variance (rm‐ANOVA) or more recently, linear …

Vascular damage in tumors: a key player in stereotactic radiation therapy?

SV Kozin - Trends in Cancer, 2022 - cell.com
The use of stereotactic radiation therapy (SRT) for cancer treatment has grown in recent
years, showing excellent results for some tumors. The greatly increased doses per fraction in …

[HTML][HTML] Binary dose level classification of tumour microvascular response to radiotherapy using artificial intelligence analysis of optical coherence tomography images

A Majumdar, N Allam, WJ Zabel, V Demidov… - Scientific Reports, 2022 - nature.com
The dominant consequence of irradiating biological systems is cellular damage, yet
microvascular damage begins to assume an increasingly important role as the radiation …

[HTML][HTML] Super-resolution imaging with ultrasound for visualization of the renal microvasculature in rats before and after renal ischemia: A pilot study

SB Andersen, I Taghavi, CAV Hoyos, SB Søgaard… - Diagnostics, 2020 - mdpi.com
In vivo monitoring of the microvasculature is relevant since diseases such as diabetes,
ischemia, or cancer cause microvascular impairment. Super-resolution ultrasound imaging …

[HTML][HTML] Emerging functional imaging biomarkers of tumour responses to radiotherapy

A Campbell, LM Davis, SK Wilkinson, RL Hesketh - Cancers, 2019 - mdpi.com
Tumour responses to radiotherapy are currently primarily assessed by changes in size.
Imaging permits non-invasive, whole-body assessment of tumour burden and guides …

Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models

JR Kaeppler, J Chen, M Buono, J Vermeer… - EMBO …, 2022 - embopress.org
The effect of radiation therapy on tumor vasculature has long been a subject of debate.
Increased oxygenation and perfusion have been documented during radiation therapy …

[HTML][HTML] Longitudinal in-vivo quantification of tumour microvascular heterogeneity by optical coherence angiography in pre-clinical radiation therapy

N Allam, W Jeffrey Zabel, V Demidov, B Jones… - Scientific Reports, 2022 - nature.com
Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment due to its logistical
and potential therapeutic benefits as compared to conventional radiotherapy. However, its …

[HTML][HTML] Raster-scan optoacoustic angiography of blood vessel development in colon cancer models

A Orlova, M Sirotkina, E Smolina, V Elagin… - Photoacoustics, 2019 - Elsevier
Raster-scan optoacoustic angiography at 532 nm wavelength with 50 μm lateral resolution
at 2 mm diagnostic depth was used for quantitative characterization of neoangiogenesis in …