Viroplasms: assembly and functions of rotavirus replication factories
G Papa, A Borodavka, U Desselberger - Viruses, 2021 - mdpi.com
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected
cells, which are intricately involved in viral replication. Two virus-encoded, non-structural …
cells, which are intricately involved in viral replication. Two virus-encoded, non-structural …
Rotavirus-induced lipid droplet biogenesis is critical for virus replication
JM Criglar, MK Estes, SE Crawford - Frontiers in Physiology, 2022 - frontiersin.org
A variety of pathogens, including viruses, bacteria and parasites, target cellular lipid droplets
for their replication. Rotaviruses (RVs) infect the villous epithelium of the small intestine and …
for their replication. Rotaviruses (RVs) infect the villous epithelium of the small intestine and …
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses
RNA viruses induce the formation of subcellular organelles that provide microenvironments
conducive to their replication. Here we show that replication factories of rotaviruses …
conducive to their replication. Here we show that replication factories of rotaviruses …
Rotavirus research: 2014–2020
Rotaviruses are major causes of acute gastroenteritis in infants and young children
worldwide and also cause disease in the young of many other mammalian and of avian …
worldwide and also cause disease in the young of many other mammalian and of avian …
Flexibility of the rotavirus NSP2 C-terminal region supports factory formation via liquid-liquid phase separation
SL Nichols, EM Nilsson, H Brown-Harding… - Journal of …, 2023 - Am Soc Microbiol
Many viruses sequester the materials needed for their replication into discrete subcellular
factories. For rotaviruses (RVs), these factories are called viroplasms, and they are formed in …
factories. For rotaviruses (RVs), these factories are called viroplasms, and they are formed in …
The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication
Rotavirus (RV) replication takes place in the viroplasms, cytosolic inclusions that allow the
synthesis of virus genome segments and their encapsidation in the core shell, followed by …
synthesis of virus genome segments and their encapsidation in the core shell, followed by …
A genetically engineered rotavirus NSP2 phosphorylation mutant impaired in viroplasm formation and replication shows an early interaction between vNSP2 and …
JM Criglar, SE Crawford, B Zhao, HG Smith… - Journal of …, 2020 - Am Soc Microbiol
Many RNA viruses replicate in cytoplasmic compartments (virus factories or viroplasms)
composed of viral and cellular proteins, but the mechanisms required for their formation …
composed of viral and cellular proteins, but the mechanisms required for their formation …
Recent advances in rotavirus reverse genetics and its utilization in basic research and vaccine development
Rotaviruses are segmented double-stranded RNA viruses with a high frequency of gene
reassortment, and they are a leading cause of global diarrheal deaths in children less than 5 …
reassortment, and they are a leading cause of global diarrheal deaths in children less than 5 …
Rotavirus as an expression platform of domains of the SARS-CoV-2 spike protein
Among vaccines administered to children are those targeting rotavirus, a segmented double-
stranded RNA virus that represents a major cause of severe gastroenteritis. To explore the …
stranded RNA virus that represents a major cause of severe gastroenteritis. To explore the …
Characterization of viroplasm-like structures by co-expression of NSP5 and NSP2 across rotavirus species A to J
Rotaviruses (RVs) are classified into nine species, A–D and F–J, with species A being the
most studied. In rotavirus of species A (RVA), replication occurs in viroplasms, which are …
most studied. In rotavirus of species A (RVA), replication occurs in viroplasms, which are …