Targeted covalent inhibitors (TCIs) are designed to bind poorly conserved amino acids by
means of reactive groups, the so-called warheads. Currently, targeting noncatalytic cysteine …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …

Cysteine side chains can exist in distinct oxidation states depending on the pH and redox
potential of the environment, and cysteine oxidation plays important yet complex regulatory …

Abnormal concentrations of biothiols such as cysteine, homocysteine and glutathione are
associated with various major diseases. In biological systems, the structural similarity and …

The thiol group of cysteine (Cys) residues, often present in the active center of the protein, is
of particular importance to protein function, which is significantly determined by the redox …

The temporal and spatial patterns of reactive oxygen species (ROS) in cells and tissues
decisively determine the plant acclimation response to diverse abiotic and biotic stresses …

The Click reaction that involves Cu (I)-catalyzed azide–alkyne cycloaddition (CuAAC) serves
as the most potent and highly dependable tool for the development of many complex …

Peptides and proteins are preponderantly emerging in the drug market, as shown by the
increasing number of biopharmaceutics already approved or under development …

Click chemistry has been established rapidly as one of the most valuable methods for the
chemical transformation of complex molecules. Due to the rapid rates, clean conversions to …