Neurodevelopmental outcome of infants who develop necrotizing enterocolitis: The gut-brain axis

J Lu, CR Martin, EC Claud - Seminars in perinatology, 2023 - Elsevier
Necrotizing enterocolitis (NEC) poses a significant risk for neurodevelopmental impairment
in extremely preterm infants. The gut microbiota shapes the development of the gut, immune …

Updates and recommendations on the surgical management of NEC

A Golubkova, CJ Hunter - Seminars in Perinatology, 2023 - Elsevier
Necrotizing enterocolitis is a severe gastrointestinal disease of the infant. It most commonly
targets those that are born prematurely. NEC has been associated with initiation of feeds …

Comparative MiRNA expressional profiles and molecular networks in human small bowel tissues of necrotizing enterocolitis and spontaneous intestinal perforation

PC Ng, KYY Chan, KT Leung, YH Tam, TPY Ma… - PloS one, 2015 - journals.plos.org
Background Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) are
acute intestinal conditions which could result in mortality and severe morbidity in preterm …

The role of ischemia in necrotizing enterocolitis

Y Chen, KTE Chang, DWQ Lian, H Lu, S Roy… - Journal of pediatric …, 2016 - Elsevier
Aim The role of ischemia in the pathogenesis of necrotizing enterocolitis (NEC) remains
unclear. We used immunohistochemical markers of hypoxia to identify presence/absence of …

Microbiota from preterm infants who develop necrotizing enterocolitis drives the neurodevelopment impairment in a humanized mouse model

J Lu, A Drobyshevsky, L Lu, Y Yu, MS Caplan… - Microorganisms, 2023 - mdpi.com
Necrotizing enterocolitis (NEC) is the leading basis for gastrointestinal morbidity and poses
a significant risk for neurodevelopmental impairment (NDI) in preterm infants. Aberrant …

Surgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age

A Humberg, J Spiegler, MI Fortmann, M Zemlin… - Scientific reports, 2020 - nature.com
Gastrointestinal complications during the neonatal period, ie necrotizing enterocolitis (NEC)
and spontaneous intestinal perforation (SIP), are associated with adverse short-term …

Intestinal perforation in the premature infant

K Vongbhavit, MA Underwood - Journal of Neonatal-Perinatal …, 2017 - content.iospress.com
OBJECTIVE: To compare demographic data, prenatal and postnatal characteristics,
laboratory data, and outcomes in a cohort of premature infants with spontaneous ileal …

Meconium‐related ileus in extremely low‐birthweight neonates: Etiological considerations from histology and radiology

A Kubota, J Shiraishi, H Kawahara… - Pediatrics …, 2011 - Wiley Online Library
Background: A nationwide survey on neonatal surgery conducted by the Japanese Society
of Pediatric Surgeons has demonstrated that the mortality of neonatal intestinal perforation …

Role of nutrition in prevention of neonatal spontaneous intestinal perforation and its complications: a systematic review

O Olaloye, M Swatski, L Konnikova - Nutrients, 2020 - mdpi.com
Background: Spontaneous intestinal perforation (SIP) is a devastating complication of
prematurity, and extremely low birthweight (ELBW< 1000 g) infants born prior to 28 weeks …

Morbidity associated with laparotomy-confirmed spontaneous intestinal perforation: A prospective multicenter analysis

K Culbreath, G Keefe, EM Edwards, KA Morrow… - Journal of Pediatric …, 2022 - Elsevier
Background Differences in morbidities between spontaneous intestinal perforation (SIP) and
necrotizing enterocolitis (NEC) are unknown. Methods Prospectively collected multicenter …