3D cell culture systems: tumor application, advantages, and disadvantages
O Habanjar, M Diab-Assaf, F Caldefie-Chezet… - International journal of …, 2021 - mdpi.com
The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …
been used in cancer research. However, this system cannot be fully translated into clinical …
Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the future
D Akhoundova, MA Rubin - Cancer Cell, 2022 - cell.com
Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …
through the identification of therapeutic targets and molecular biomarkers, leading to the …
3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs
Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …
alternatives for initial drug screening to increase drug development efficiency. In addition to …
Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling
Highlights•Traditional drug screening model systems are inadequate.•Organoid-on-a-chip
platforms stand to significantly advance drug and toxicology screening.•A wide variety or …
platforms stand to significantly advance drug and toxicology screening.•A wide variety or …
3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare
In the last few years, 3D printing has emerged as a promising alternative for the fabrication
of microfluidic devices, overcoming some of the limitations associated with conventional soft …
of microfluidic devices, overcoming some of the limitations associated with conventional soft …
Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …
provide similar metabolism, proliferation, and species concentration gradients to those found …
A microfluidics platform for combinatorial drug screening on cancer biopsies
F Eduati, R Utharala, D Madhavan… - Nature …, 2018 - nature.com
Screening drugs on patient biopsies from solid tumours has immense potential, but is
challenging due to the small amount of available material. To address this, we present here …
challenging due to the small amount of available material. To address this, we present here …
Microsensor systems for cell metabolism–from 2D culture to organ-on-chip
Microsensor systems for cell metabolism are essential tools for investigation and
standardization in cell culture. Electrochemical and optical read-out schemes dominate …
standardization in cell culture. Electrochemical and optical read-out schemes dominate …
Replacement, reduction, and refinement of animal experiments in anticancer drug development: the contribution of 3D in vitro cancer models in the drug efficacy …
In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …
Microfluidic trends in drug screening and drug delivery
The low probability of a drug candidate's clinical success, the time consumed and the high
cost of bringing a drug from concept to market emphasizes the need for new approaches to …
cost of bringing a drug from concept to market emphasizes the need for new approaches to …