Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune system and fibrosis in the skin and internal organs. The …

Fibrosis is the excessive deposition of a stable extracellular matrix (ECM); fibrotic tissue is
composed principally of highly crosslinked type I collagen and highly contractile …

Fibrosis, a process caused by excessive deposition of extracellular matrix (ECM), is a
common cause and outcome of organ failure and even death. Researchers have made …

IL-17 (IL-17A) is a pro-inflammatory cytokine produced by a sub-set of T helper cells termed
Th17 cells primarily in response to cytokines like TGF-β and IL-23 and play an important role …

There are two major clinical subsets of scleroderma:(i) systemic sclerosis (SSc) is a complex
systemic autoimmune disorder characterized by inflammation, vasculopathy, and excessive …

Exposure to crystalline silica (CS) particles in worksites and dwellings can lead to silicosis
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …

Objective To determine contributions and functions of autoantibodies (Abs) directed to the
angiotensin receptor type 1 (AT1R), which are suggested to be involved in the pathogenesis …

Introduction NOD-like receptor family pyrin domain containing 3 (NLRP3) can sense a
plethora of exogenous and endogenous dangers. Upon activation, a multimeric protein …

Abstract Objectives Interleukin 11 (IL11) is highly upregulated in skin and lung fibroblasts
from patients with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically …

Systemic sclerosis (SSc) is a complex, immune-mediated rheumatic disease characterised
by excessive extracellular matrix deposition in the skin and internal organs. B cell infiltration …