Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
PfCRT and its role in antimalarial drug resistance
Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
F Ariey, B Witkowski, C Amaratunga, J Beghain… - Nature, 2014 - nature.com
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Chemogenetic characterization through in vitro evolution combined with whole-genome
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
SH Adjalley, GL Johnston, T Li… - Proceedings of the …, 2011 - National Acad Sciences
Clinical studies and mathematical models predict that, to achieve malaria elimination,
combination therapies will need to incorporate drugs that block the transmission of …
combination therapies will need to incorporate drugs that block the transmission of …
Drug resistance in eukaryotic microorganisms
Eukaryotic microbial pathogens are major contributors to illness and death globally.
Although much of their impact can be controlled by drug therapy as with prokaryotic …
Although much of their impact can be controlled by drug therapy as with prokaryotic …
[HTML][HTML] Artemisinin-resistant malaria: research challenges, opportunities, and public health implications
RM Fairhurst, GML Nayyar, JG Breman… - The American journal …, 2012 - ncbi.nlm.nih.gov
Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium
falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the …
falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the …
Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases
Malaria afflicts over 200 million people worldwide, and its most lethal etiologic agent,
Plasmodium falciparum, is evolving to resist even the latest-generation therapeutics …
Plasmodium falciparum, is evolving to resist even the latest-generation therapeutics …
Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance
JS Gilleard - Parasitology, 2013 - cambridge.org
Anthelmintic resistance is a major problem for the control livestock parasites and a potential
threat to the sustainability of community-wide treatment programmes being used to control …
threat to the sustainability of community-wide treatment programmes being used to control …
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt
S Pelleau, EL Moss, SK Dhingra… - Proceedings of the …, 2015 - National Acad Sciences
In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line
treatment of Plasmodium falciparum infections has typically led to the restoration of CQ …
treatment of Plasmodium falciparum infections has typically led to the restoration of CQ …