Overcoming anti-PD-1/PD-L1 immune checkpoint blockade resistance: the role of macrophage, neutrophils and mast cells in the tumor microenvironment

LB Kwantwi - Clinical and Experimental Medicine, 2023 - Springer
In recent years, the anti-PD-1/PD-L1 blockade has become a game changer in cancer
treatment following the unprecedented response rate. Regardless of the substantial therapy …

Exosome-mediated crosstalk between tumor cells and innate immune cells: implications for cancer progression and therapeutic strategies

LB Kwantwi - Journal of cancer research and clinical oncology, 2023 - Springer
The increasing number of cancer-associated deaths despite the substantial improvement in
diagnosis and treatment has sparked discussions on the need for novel biomarkers and …

Focal adhesion kinase-mediated interaction between tumor and immune cells in the tumor microenvironment: Implications for cancer-associated therapies and tumor …

LB Kwantwi, T Tandoh - Clinical and Translational Oncology, 2024 - Springer
Focal adhesion kinase (FAK) expression has been linked to tumor growth,
immunosuppression, metastasis, angiogenesis, and therapeutic resistance through kinase …

The dual and multifaceted role of relaxin-2 in cancer

LB Kwantwi - Clinical and Translational Oncology, 2023 - Springer
The continuous increase in cancer-associated deaths despite the substantial improvement
in diagnosis and treatment has sparked discussions on the need for novel biomarkers and …

Neutrophil infiltration associated genes on the prognosis and tumor immune microenvironment of lung adenocarcinoma

R Liu, G Zhu, Y Sun, M Li, Z Hu, P Cao, X Li… - Frontiers in …, 2023 - frontiersin.org
The neutrophils exhibit both anti-tumor and pro-tumor effects in cancers. The correlation
between neutrophils and tumor development in lung adenocarcinoma (LUAD) is still …

SLAM family-mediated crosstalk between tumor and immune cells in the tumor microenvironment: A promising biomarker and a potential therapeutic target for immune …

LB Kwantwi - Clinical and Translational Oncology, 2024 - Springer
Immune cells infiltrating the tumor microenvironment are physiologically important in
controlling cancers. However, emerging studies have shown that cancer cells can evade …

Tumor-activated neutrophils promote metastasis in breast cancer via the G-CSF-RLN2-MMP-9 axis

Y Sheng, W Peng, Y Huang, L Cheng… - Journal of Leukocyte …, 2023 - academic.oup.com
The immune component of the tumor microenvironment is essential for the regulation of
cancer progression. In breast cancer (BC), a patient's tumor mass is frequently infiltrated by …

Genetic alterations shape innate immune cells to foster immunosuppression and cancer immunotherapy resistance

LB Kwantwi - Clinical and Experimental Medicine, 2023 - Springer
Cancer immunotherapy, particularly immune checkpoint inhibitors, has opened a new
avenue for cancer treatment following the durable clinical benefits. Despite the clinical …

Extracellular vesicles in non-small cell lung cancer stemness and clinical applications

P Pandya, DS Al-Qasrawi, S Klinge… - Frontiers in …, 2024 - frontiersin.org
Non-small cell lung carcinoma (NSCLC) accounts for 85% of lung cancers, the leading
cause of cancer associated deaths in the US and worldwide. Within NSCLC tumors, there is …

[HTML][HTML] The Tumor Microenvironment as a Therapeutic Target in Cutaneous T Cell Lymphoma

LB Kwantwi, ST Rosen, C Querfeld - Cancers, 2024 - mdpi.com
Simple Summary Cutaneous T cell lymphomas (CTCLs) are a group of rare
lymphoproliferative malignancies manifesting in the skin. Cutaneous T cell lymphomas are …