Ubiquitin is important for nearly every aspect of cellular physiology. All viruses rely
extensively on host machinery for replication; therefore, it is not surprising that viruses …

Degrons are the elements that are used by E3 ubiquitin ligases to target proteins for
degradation. Most degrons are short linear motifs embedded within the sequences of …

Although generally curable with intensive chemotherapy in resource-rich settings, Burkitt
lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa …

We have discovered a ubiquitin (Ub)-specific cysteine protease encoded within the N-
terminal∼ 500 residues of the UL36 gene product, the largest (3164 aa) tegument protein of …

Highlights•USP7, a widely studied deubiquitinating enzyme, spares substrates from
proteasome degradation.•USP7 interacts with many proteins whose alterations promote …

Proteases play a key role in various pathological processes and several protease inhibitors
are already available for treatment. DUBs (deubiquitinating enzymes) constitute one of the …

The life cycle of Epstein–Barr virus (EBV) is intriguing in that the virus resides within the
immune system and utilizes distinct latency expression programs to establish a persistent …

Influenza A virus RNA replication requires an intricate regulatory network involving viral and
cellular proteins. In this study, we examined the roles of cellular ubiquitinating …

Through the combined action of ubiquitinating and deubiquitinating enzymes, conjugation of
ubiquitin to a target protein acts as a reversible post-translational modification functionally …

The Epstein–Barr virus (EBV)-encoded EBNA1 protein is expressed in all virus-associated
tumours, including nasopharyngeal carcinoma (NPC), where it plays an essential role in …