[HTML][HTML] Hallmarks of aging: An expanding universe
Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies
Y Lu, X Yuan, M Wang, Z He, H Li, J Wang… - Journal of hematology & …, 2022 - Springer
The gut microbiota have long been recognized to play a key role in human health and
disease. Currently, several lines of evidence from preclinical to clinical research have …
disease. Currently, several lines of evidence from preclinical to clinical research have …
Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial
Fecal microbiota transplantation (FMT) represents a potential strategy to overcome
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …
[HTML][HTML] Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
The use of probiotics by cancer patients is increasing, including among those undergoing
immune checkpoint inhibitor (ICI) treatment. Here, we elucidate a critical microbial-host …
immune checkpoint inhibitor (ICI) treatment. Here, we elucidate a critical microbial-host …
A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy
Increasing evidence suggests that the gut microbiome may modulate the efficacy of cancer
immunotherapy. In a B cell lymphoma patient cohort from five centers in Germany and the …
immunotherapy. In a B cell lymphoma patient cohort from five centers in Germany and the …
T cells specific for α-myosin drive immunotherapy-related myocarditis
ML Axelrod, WC Meijers, EM Screever, J Qin… - Nature, 2022 - nature.com
Immune-related adverse events, particularly severe toxicities such as myocarditis, are major
challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy. The …
challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy. The …
Diet-driven microbial ecology underpins associations between cancer immunotherapy outcomes and the gut microbiome
RC Simpson, ER Shanahan, M Batten, ILM Reijers… - Nature medicine, 2022 - nature.com
The gut microbiota shapes the response to immune checkpoint inhibitors (ICIs) in cancer,
however dietary and geographic influences have not been well-studied in prospective trials …
however dietary and geographic influences have not been well-studied in prospective trials …
The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer
The composition of the gut microbiome can control innate and adaptive immunity and has
emerged as a key regulator of tumor growth, especially in the context of immune checkpoint …
emerged as a key regulator of tumor growth, especially in the context of immune checkpoint …
Targeting the gut microbiota for cancer therapy
Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …
Machine learning for microbiologists
Abstract Machine learning is increasingly important in microbiology where it is used for tasks
such as predicting antibiotic resistance and associating human microbiome features with …
such as predicting antibiotic resistance and associating human microbiome features with …