The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place
of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic …

Cerebral small vessel diseases (SVDs) range broadly in etiology but share remarkably
overlapping pathology. Features of SVD including enlarged perivascular spaces (EPVS) …

Despite the enormous progress in the understanding of the course of the ischemic stroke
over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and …

The glymphatic system is a brainwide CSF transport system that uses the perivascular space
for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and …

The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …

The complex and dynamic system of fluid flow through the perivascular and interstitial
spaces of the CNS has new-found implications for neurological diseases. CSF movement …

In intracerebral hemorrhage (ICH), delayed secondary neural damages largely occur from
perihematomal edema (PHE) resulting from the disruption of the blood–brain barrier (BBB) …

Hypertension is the leading cause of cardiovascular affection and premature death
worldwide. The spontaneously hypertensive rat (SHR) is the most common animal model of …

Cerebral small vessel disease (CSVD, cerebral microangiopathy) leads to dementia and
stroke-like symptoms. Lacunes, white matter lesions (WML) and microbleeds are the main …