Targeting CD24/Siglec-10 signal pathway for cancer immunotherapy: recent advances and future directions

X Li, W Tian, Z Jiang, Y Song, X Leng, J Yu - Cancer Immunology …, 2024 - Springer
The small, heavily glycosylated protein CD24 is primarily expressed by many immune cells
and is highly expressed mostly in cancer cells. As one of the most crucial biomarkers of …

[HTML][HTML] CD24 as a potential therapeutic target in patients with B-cell leukemia and lymphoma: current insights

SL Christian - OncoTargets and therapy, 2022 - ncbi.nlm.nih.gov
CD24 is a highly glycosylated glycophosphatidylinositol (GPI)-anchored protein that is
expressed in many types of differentiating cells and some mature cells of the immune system …

The role of the astrocyte in subarachnoid hemorrhage and its therapeutic implications

R Li, M Zhao, D Yao, X Zhou, C Lenahan… - Frontiers in …, 2022 - frontiersin.org
Subarachnoid hemorrhage (SAH) is an important public health concern with high morbidity
and mortality worldwide. SAH induces cell death, blood− brain barrier (BBB) damage, brain …

Surprising magic of CD24 beyond cancer

H Wang, P Shi, X Shi, Y Lv, H Xie, H Zhao - Frontiers in Immunology, 2024 - frontiersin.org
CD24 has emerged as a molecule of significant interest beyond the oncological arena.
Recent studies have unveiled its surprising and diverse roles in various biological …

P38-DAPK1 axis regulated LC3-associated phagocytosis (LAP) of microglia in an in vitro subarachnoid hemorrhage model

XX Chen, T Tao, XZ Liu, W Wu, JW Wang… - Cell Communication and …, 2023 - Springer
Background The phagocytosis and homeostasis of microglia play an important role in
promoting blood clearance and improving prognosis after subarachnoid hemorrhage (SAH) …

Dexmedetomidine Attenuates Neuroinflammation-Mediated Hippocampal Neurogenesis Impairment in Sepsis-Associated Encephalopathy Mice through Central α2A …

X Zhang, Y Feng, Y Zhong, R Ding, Y Guo… - ACS chemical …, 2024 - ACS Publications
Sepsis-associated encephalopathy (SAE), one of the common complications of sepsis, is
associated with higher ICU mortality, prolonged hospitalization, and long-term cognitive …

Targeting Shp2 as a therapeutic strategy for neurodegenerative diseases

J Pang, C Cen, Y Tian, X Cao, L Hao, X Tao… - Translational …, 2025 - nature.com
The incidence of neurodegenerative diseases (NDs) has increased recently. However, most
of the current governance strategies are palliative and lack effective therapeutic drugs …

Unravelling CD24‐Siglec‐10 pathway: Cancer immunotherapy from basic science to clinical studies

R Hazra, S Chattopadhyay, A Mallick, S Gayen… - …, 2024 - Wiley Online Library
Cancer immunotherapy has revolutionized the treatment landscape by harnessing the
power of the immune system to combat malignancies. Two of the most promising players in …

Targeting the CD24-Siglec10 Axis: A Potential Strategy for Cancer Immunotherapy

J Fang, L Lin, J Tan, Y Liang, X Xiao, N Ouyang… - BIO …, 2024 - scienceopen.com
CD24, also known as heat-stable protein, is a highly glycosylated
glycosylphosphatidylinositol junction membrane protein. CD24 specifically binds sialic-acid …

Therapeutic potential of stem cells in subarachnoid hemorrhage

H Kanamaru, H Suzuki - Neural Regeneration Research, 2025 - journals.lww.com
Aneurysm rupture can result in subarachnoid hemorrhage, a condition with potentially
severe consequences, such as disability and death. In the acute stage, early brain injury …