The treatment of sepsis and septic shock remains a major public health issue due to the
associated morbidity and mortality. Despite an improvement in the understanding of the …

Sepsis carries a substantial risk of morbidity and mortality in newborns, especially preterm-
born neonates. Endothelial glycocalyx (eGC) is a carbohydrate-rich layer lining the vascular …

Background The concomitant occurrence of the symptoms intravascular hypovolemia,
peripheral edema and hemodynamic instability is typically named Capillary Leak Syndrome …

Pneumonia is the leading cause of post-neonatal death amongst children under five years of
age; however, there is no simple triage tool to identify children at risk of progressing to …

Endothelial dysfunction plays a central role in the pathogenesis of sepsis-mediated multiple
organ failure. Several clinical and experimental studies have suggested that the glycocalyx …

Millions of infants are born prematurely every year worldwide. Prematurity, particularly at
lower gestational ages, is associated with high mortality and morbidity and is a significant …

Recent evidence has shown that microRNAs (miRs) are involved in endothelial dysfunction
and vascular injury in lung-related diseases. However, the potential role of miR-34a in the …

Antibiotic overprescribing is prevalent in pediatric emergency medicine, influenced by
clinician–caregiver dynamics and diagnostic uncertainties, and poses substantial risks such …

Background Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated
host response to infection, has become one of the major causes of death in Intensive Care …

Early diagnosis and accurate prognosis are key for reducing the fatality rate and medical
expenses associated with sepsis. Platelets are involved in the delayed tissue injury that …