No effective therapy is currently available to promote recovery following ischemic stroke.
Stem cells have been proposed as a potential source of new cells to replace those lost due …

Retinal stem cells (RSCs) are multipotent central nervous system (CNS) precursors that give
rise to the retina during the course of development. RSCs are present in the embryonic …

Microglia are crucially important myeloid cells in the CNS and constitute the first
immunological barrier against pathogens and environmental insults. The factors controlling …

Specialized cellular microenvironments, or 'niches', modulate stem cell properties, including
cell number, self-renewal and fate decisions,. In the adult brain, niches that maintain a …

Inflammatory agonists such as lipopolysaccharide (LPS) induce robust systemic as well as
CNS responses after peripheral administration. Responses in the innate immune system …

Reports of neural transdifferentiation of mesenchymal stem cells (MSCs) suggest the
possibility that these cells may serve as a source for stem cell–based regenerative medicine …

Bone marrow stromal cells (MSC), which represent a population of multipotential
mesenchymal stem cells, have been reported to undergo rapid and robust transformation …

Contusive spinal cord injury (SCI) produces large fluid-, debris-and inflammatory cell-filled
cystic cavities that lack structure to support significant axonal regeneration. The recent …

Amyotrophic lateral sclerosis (ALS) is a lethal disease affecting motoneurons. In familial
ALS, patients bear mutations in the superoxide dismutase gene (SOD1). We transplanted …

The role of microglia recruited from bone marrow (BM) into the CNS during the progression
of Alzheimer's disease (AD) is poorly understood. To investigate whether β-amyloid (Aβ) …