[HTML][HTML] Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

L Lin, J Chi, Y Yan, R Luo, X Feng, Y Zheng… - … Pharmaceutica Sinica B, 2021 - Elsevier
Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or
anticarcinogens that present a general killing mechanism through the physical disruption of …

Antimicrobial peptides and cationic nanoparticles: a broad-spectrum weapon to fight multi-drug resistance not only in bacteria

GE Valenti, S Alfei, D Caviglia, C Domenicotti… - International journal of …, 2022 - mdpi.com
In the last few years, antibiotic resistance and, analogously, anticancer drug resistance have
increased considerably, becoming one of the main public health problems. For this reason, it …

Cationic polysaccharide conjugates as antibiotic adjuvants resensitize multidrug‐resistant bacteria and prevent resistance

S Mu, Y Zhu, Y Wang, S Qu, Y Huang… - Advanced …, 2022 - Wiley Online Library
In recent years, traditional antibiotic efficacy has rapidly diminished due to the advent of
multidrug‐resistant (MDR) bacteria, which poses severe threat to human life and globalized …

Titanium carbide MXene-based hybrid hydrogel for chemo-photothermal combinational treatment of localized bacterial infection

Y Zheng, Y Yan, L Lin, Q He, H Hu, R Luo, D Xian… - Acta Biomaterialia, 2022 - Elsevier
With the increased emergence and threat of multi-drug resistant microorganisms, MXenes
have become not only an emerging class of two-dimensional functional nanomaterials, but …

Short guanidinium‐functionalized poly (2‐oxazoline) s displaying potent therapeutic efficacy on drug‐resistant fungal infections

W Jiang, M Zhou, Z Cong, J Xie, W Zhang… - Angewandte …, 2022 - Wiley Online Library
New antifungals are urgently needed to combat invasive fungal infections, due to limited
types of available antifungal drugs and frequently encountered side effects, as well as the …

Guanidinium-based ionic covalent organic frameworks for capture of uranyl tricarbonate

Y Liang, M Xia, Q Yu, Y Li, Z Sui, Y Yuan… - … Composites and Hybrid …, 2022 - Springer
Uranium, which was abundant in the ocean but existed in the form of uranyl tricarbonate
([UO 2 (CO 3) 3] 4−) with an extremely low concentration of 3.3 ppb, was a significant …

An effective strategy to develop potent and selective antifungal agents from cell penetrating peptides in tackling drug-resistant invasive fungal infections

Y Wu, W Jiang, Z Cong, K Chen, Y She… - Journal of Medicinal …, 2022 - ACS Publications
The high mortality rate of invasive fungal infections and quick emergence of drug-resistant
fungal pathogens urgently call for potent antifungal agents. Inspired by the cell penetrating …

Unnatural amino‐acid‐based star‐shaped poly (L‐Ornithine) s as emerging long‐term and biofilm‐disrupting antimicrobial peptides to treat Pseudomonas aeruginosa …

M Pan, C Lu, M Zheng, W Zhou, F Song… - Advanced …, 2020 - Wiley Online Library
Peptide‐based antimicrobial materials are recognized as promising alternatives to
antibiotics to circumvent the emergence of antibiotic‐resistant bacteria or to combat multiple …

Modular design of membrane-active antibiotics: from macromolecular antimicrobials to small scorpionlike peptidomimetics

M Wang, X Feng, R Gao, P Sang, X Pan… - Journal of medicinal …, 2021 - ACS Publications
Infections caused by multidrug-resistant bacteria have emerged in recent decades, leading
to escalating interest in host defense peptides (HDPs) to reverse this dangerous trend …

Aggregation-induced emission active metal complexes: A promising strategy to tackle bacterial infections

P Prasad, A Gupta, PK Sasmal - Chemical Communications, 2021 - pubs.rsc.org
Bacterial infection is a major global threat to human health and currently one of the leading
causes of death worldwide. The development of probes for rapid diagnosis of bacteria with …