Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis.
Recent years have witnessed increasing interest towards the use of highly active and …

Enantioselective reactions catalyzed by small organic molecules (asymmetric
organocatalysis) have emerged as one of the most elegant cutting-edge strategies of …

Spirooxindoles have become a privileged skeleton given their broad and promising
activities in various therapeutic areas. The strategies and catalyst systems described here …

A‐spiro‐ing: The title reaction of α‐isothiocyanato imides and methyleneindolinones has
been realized for the first time using 1 as the catalyst. This newly developed synthetic …

Drug-lead synthesis through rapid construction of chiral molecular complexity around the
biologically relevant framework using a highly efficient strategy is a key goal of organic …

Function-oriented design and synthesis of chiral small molecules with novel activity is a key
goal in modern organic chemistry. As multiple antibiotic-resistant pathogens are emerging …

Heterocycles are an important class of organic compounds accounting for nearly one-third of
the past decade's publications, which are in the field of heterocyclic chemistry. In fact, two …

A wide range of structurally diverse 3, 3′-thiopyrrolidonyl spirooxindoles bearing three
contiguous stereogenic centers can be smoothly obtained via a domino Michael/cyclization …

The first example of a direct catalytic asymmetric intermolecular aldol reaction of 3-
isothiocyanato oxindoles to simple ketones with bifunctional thiourea-tertiary amine as …

For almost 20 years, thioureas have been experiencing a renaissance of interest with the
emerged development of asymmetric organocatalysts. Due to their relatively high acidity and …