The field of medicinal inorganic chemistry has evolved with three conceptual aims: the
introduction of metal ions to the biological system, manipulation and redistribution of metal …

The family of hydroxypyrones and close congeners, the hydroxypyridinones, is a particularly
versatile class of ligands. The most widely investigated for medicinal applications are the 3 …

Ascorbic acid (AscH2) is one of the most important vitamins found in the human diet, with
many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic …

The synthesis of a range of novel bidentate ligands containing the chelating moiety 3-
hydroxy-4 (lH)-pyridinone is described. The pKa values of the ligands and the stability …

The solution chemistry of the hydrolytic, early-transition-metal ions Ti4+ and Sc3+ represents
a coordination chemistry challenge with important real-world implications, specifically in the …

Simple, high-yield, large-scale syntheses of the V (III) complexes tris (maltolato) vanadium
(III), V (ma) 3, tris (ethylmaltolato) vanadium (III), V (ema) 3, tris (kojato) vanadium (III) …

Publisher Summary This chapter discusses the clinically useful chelators of tripositive
elements. The clinical use of chelator molecules has been synonymous with the removal of …

The iron (III)–1, 2-dimethyl-3-hydroxy-4-pyridinone (Deferiprone) system is carefully
characterized by a combined potentiometric–spectrophotometric procedure at 25 and 37° C …

Despite its prevalence in the environment, the chemistry of the Ti4+ ion has long been
relegated to organic solutions or hydrolyzed TiO2 polymorphs. A knowledge gap in …

Derivatives of 3, 4-hydroxypyridinones have been extensively studied for in vivo Fe3+
sequestration. Deferiprone, a 1, 2-dimethyl-3, 4-hydroxypyridinone, is now routinely used for …