Synthesis and transformations of nitrones for organic synthesis

SI Murahashi, Y Imada - Chemical reviews, 2019 - ACS Publications
Nitrones are important compounds and are highly useful in many aspects. The first part
describes the methods for synthesis of nitrones, which are useful and environmentally …

Synthesis of Hypervalent Iodine Diazo Compounds and Their Application in Organic Synthesis

C Zhang, JP Wan - Chemistry–A European Journal, 2024 - Wiley Online Library
Diazomethyl‐substituted iodine (III) compounds with electron‐withdrawing groups (EWG)
connected to diazo methyl center were a type of donor‐acceptor diazo compounds with …

C–H bond functionalization of amines: a graphical overview of diverse methods

S Dutta, B Li, DRL Rickertsen, DA Valles, D Seidel - SynOpen, 2021 - thieme-connect.com
Thieme E-Journals - SynOpen / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SynOpen Full-text search Full-text search Author …

Cooperative Multifunctional Catalysts for Nitrone Synthesis: Platinum Nanoclusters in Amine‐Functionalized Metal–Organic Frameworks

X Li, B Zhang, L Tang, TW Goh, S Qi… - Angewandte …, 2017 - Wiley Online Library
Nitrones are key intermediates in organic synthesis and the pharmaceutical industry. The
heterogeneous synthesis of nitrones with multifunctional catalysts is extremely attractive but …

Asymmetric nitrone synthesis via ligand-enabled copper-catalyzed cope-type hydroamination of cyclopropene with oxime

Z Li, J Zhao, B Sun, T Zhou, M Liu, S Liu… - Journal of the …, 2017 - ACS Publications
We report realization of the first enantioselective Cope-type hydroamination of oximes for
asymmetric nitrone synthesis. The ligand promoted asymmetric cyclopropene …

Mannich‐type reactions of cyclic nitrones: effective methods for the enantioselective synthesis of piperidine‐containing alkaloids

VG Lisnyak, T Lynch‐Colameta… - Angewandte Chemie …, 2018 - Wiley Online Library
Even though there are dozens of biologically active 2‐substituted and 2, 6‐disubstituted
piperidines, only a limited number of approaches exist for their synthesis. Herein is …

Metal-free organocatalytic oxidative Ugi reaction promoted by hypervalent iodine

K Singh, A Kaur, VS Mithu… - The Journal of Organic …, 2017 - ACS Publications
We report here a novel IBX-promoted oxidative coupling of primary amines and its utilization
to Ugi reaction. Advantageously, the reaction could be carried out in choline chloride urea …

Piperidine azasugars bearing lipophilic chains: stereoselective synthesis and biological activity as inhibitors of glucocerebrosidase (GCase)

F Clemente, C Matassini, S Giachetti… - The Journal of …, 2021 - ACS Publications
We report a straightforward synthetic strategy for the preparation of trihydroxypiperidine
azasugars decorated with lipophilic chains at both the nitrogen and the adjacent carbon as …

Visible-light-promoted nitrone synthesis from nitrosoarenes under catalyst-and additive-free conditions

BG Cai, L Li, GY Xu, WJ Xiao, J Xuan - Photochemical & Photobiological …, 2021 - Springer
A green and sustainable nitrone formation reaction via visible-light-promoted reaction of aryl
diazoacetates with nitrosoarenes is described. This protocol exhibits good functional group …

Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning

F Clemente, C Matassini, C Faggi, S Giachetti… - Bioorganic …, 2020 - Elsevier
The enzyme glucocerebrosidase (GCase) has become an important therapeutic target due
to its involvement in pathological disorders consequent to enzyme deficiency, such as the …