Drug-resistant tuberculosis is a major public health concern in many countries. Over the past
decade, the number of patients infected with Mycobacterium tuberculosis resistant to the …

The causative agent of tuberculosis (TB), Mycobacterium tuberculosis and more recently
totally drug‐resistant strains of M. tuberculosis, display unique mechanisms to survive in the …

Background: The American Thoracic Society, US Centers for Disease Control and
Prevention, European Respiratory Society, and Infectious Diseases Society of America …

ALTHOUGH CURABLE, TB frequently leaves the individual with chronic physical and
psycho-social impairment, but these consequences have been largely neglected. The 1st …

This analysis of the global clinical antibacterial pipeline was done in support of the Global
Action Plan on Antimicrobial Resistance. The study analysed to what extent antibacterial …

Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and
impose a heavy economic burden on affected countries. These diseases predominantly …

Boosting immune cell function by targeting the coinhibitory receptor PD-1 may have
applications in the treatment of chronic infections. Here, we examine the role of PD-1 during …

Tuberculosis (TB) is the most common cause of death from infectious disease worldwide. A
substantial proportion of patients presenting with extrapulmonary TB have urogenital TB (UG …

Macrophages help defend the host against Mycobacterium tuberculosis (Mtb), the major
cause of tuberculosis (TB). Once phagocytized, Mtb resists killing by macrophages …

Evidence-based guidance is needed on 1) how tuberculosis (TB) infectiousness evolves in
response to effective treatment and 2) how the TB infection risk can be minimised to help …